Marlene Busko, for Medscape July 28, 2022 The study covered in this summary was published on medRxiv as a preprint and has not yet been peer reviewed. Key Takeaways In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident...
Tag: <span>Diabetes</span>
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Gut microbe peptide implicated in triggering type 1 diabetes
by Joslin Diabetes Center Credit: Pixabay/CC0 Public Domain In type 1 diabetes, the body develops immune cells that target pancreatic beta cells, which play a critical role in the production and secretion of insulin. One of the earliest targets of this immune response is a specific sequence of amino acids, or peptide, within the insulin...
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A new pathway to the regeneration of insulin could mean a major breakthrough in diabetes treatment
by could mean a major breakthrough toward new therapies for Type 1 and Type 2 diabetes, Monash University Credit: Pixabay/CC0 Public Domain A world-first study by Monash University, in Melbourne, Australia has discovered a pathway to the regeneration of insulin in pancreatic stem cells, a major breakthrough toward new therapies to treat Type 1 and Type...
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Diabetes: A step closer to a life without insulin
by University of Geneva S100A9 suppresses diabetic ketogenesis via hepatic TLR4. A Scheme indicating the generation of RIP-DTR;Tlr4WT (n = 5), RIP-DTR;Tlr4WT; S100A9OE (n = 6), RIP-DTR;Tlr4KO; S100A9OE (n = 7) and RIP-DTR;Tlr4Liver; S100A9OE (n = 6) experimental groups. Adenoviral injections and HTVI were done 3 days before or the same day of the first DT injection, respectively. B Plasma insulin levels of mice at day 0...
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Sight of mouthwatering meals triggers inflammation linked to diabetes
By Nick Lavars July 03, 2022 A new study has shown that the anticipation of a meal can drive inflammatory responses before we even have the first bite Depositphotos The sight of a mouthwatering dish can certainly be enough to send our senses into overdrive, and a new study has demonstrated how the mechanisms behind...
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Light during sleep for older adults is linked to obesity, diabetes, high blood pressure
by Northwestern University Credit: Unsplash/CC0 Public Domain In a sample of older men and women ages 63 to 84, those who were exposed to any amount of light while sleeping at night were significantly more likely to be obese, and have high blood pressure and diabetes compared to adults who were not exposed to any light...
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Research reveals how key diabetes drug is made in nature
by Steve Lundeberg, Oregon State University Acarbose biosynthesis in Actinoplanes sp. SE50/110. a Acarbose biosynthetic gene cluster from Actinoplanes sp. SE50/110; b Proposed acarbose biosynthetic pathways. The thick purple arrows (shaded in blue) indicate steps that have been characterized biochemically prior to this study. The blue and red arrows indicate previously proposed pathways. The thick black...
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Popular drug may have new benefit in men with diabetes, but not women, study shows
By Akila Muthukumar June 15, 2022 ADOBE Anew study finds that a popular erectile dysfunction drug, which is increasingly being used to try to prevent heart complications in people with type 2 diabetes, doesn’t benefit women with diabetes. Only one previous randomized study examining the heart benefits of erectile dysfunction drug for patients with diabetes enrolled...
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Researchers develop pancreatic beta-cell restoring therapy for treating type 1 diabetes
by The Endocrine Society A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and...
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Scientists discover intergenerational ‘memory’ mechanism of diabetes
by Zhejiang University Schematic diagram of maternal epigenetic mechanism of glucose intolerance caused by TET3 dysfunction. Credit: Team led by Prof. Huang Hefeng Symptomatic treatment has been a common approach to chronic diseases in the past. For example, diabetes is treated by controlling the increase of glucose and alleviating various diabetes-induced complications with insulin. How...