Reviewed by Emily Henderson, B.Sc. ANCA-associated vasculitis (AAV) is a systemic disease involving the formation of special autoantibodies (so-called anti-neutrophil cytoplasmic antibodies/ANCA) and vascular inflammation. There are several diseases associated with involvement of the kidneys, lungs, upper respiratory tract, heart, skin and the nervous system; potentially life-threatening courses of disease are also possible. Immunosuppressive therapy...
Tag: <span>diseases</span>
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New killing mechanism discovered in ‘game-changing’ antibiotic
Scientists at the University of Liverpool and University of Utrecht have taken another step forward on their quest to develop a viable drug based on teixobactin – a new class of potent natural antibiotic capable of killing superbugs. Research published in Nature Communications provides fundamental new insights into how teixobactins kill bacteria, including the discovery...
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Haima Therapeutics licenses synthetic platelet technology from CWRU for hemostatic therapy
Haima Therapeutics has executed an exclusive license agreement with Case Western Reserve University to research, develop, and market artificial platelet technologies to treat patients with various bleeding disorders. The core technologies were developed in the laboratory of Professor Anirban Sen Gupta, a pioneering researcher in platelet-inspired technologies in the Department of Biomedical Engineering at the...
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Microrobots Roll Along Blood Vessel Walls to Deliver Drugs
Precise delivery of therapeutic drugs into diseased tissue remains a challenge in a variety of cases. Tumors can be hard to seed with chemo agents, particularly when the blood flow is not favorable for delivery. Now, researchers at the Max Planck Institute for Intelligent Systems in Germany have developed microscopic drug delivery devices that can...
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Vision and balance issues are common in elementary school-age children with a concussion
Collaborative research between CHOP and CDC stresses importance of proper assessments at initial health care visit CHILDREN’S HOSPITAL OF PHILADELPHIA Philadelphia, June 4, 2020 – Head injuries that lead to concussions can happen at any age, and children impacted by concussions have different needs and recovery patterns. In a new study, researchers at Children’s Hospital...
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From the research lab to your doctor’s office – here’s what happens in phase 1, 2, 3 drug trials
For COVID-19, like all illnesses, the drugs and vaccines to treat or prevent the disease must be backed by rigorous evidence. Clinical trials are the source of this evidence. With vaccines and drugs for the coronavirus already entering human testing, it is important to know what the different phases of clinical trials are testing for....
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A few months of vaping puts healthy people on the brink of oral disease
by Emily Caldwell, The Ohio State University Scientists who’ve taken the first look at bacteria in young and healthy vapers’ mouths say that the potential for future disease lies just below the surface. The collection of oral bacteria in daily e-cigaretteusers’ mouths is teeming with potent infection-causing organisms that put vapers at substantial risk for...
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Genetic database provides rare disease clues and Parkinson’s hope
by Kate Wighton, Imperial College London Scientists have created the world’s largest publicly available database of genetic variants—changes in DNA that can sometimes lead to disease. The use of this resource, called the Genome Aggregation Database (gnomAD) and including information from over 140,000 people from across the globe, is described in a landmark collection of...
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Stimulating immune cleanup crew offers a possibility for treating rare disorder
by Katherine Unger Baillie, University of Pennsylvania By mimicking the cellular cleanup process known as efferocytosis, researchers from the School of Dental Medicine have identified a new strategy for addressing a rare genetic disease that causes inflammation around the body. Credit: George Hajishengallis Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type...
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Researchers test new treatment protocol for lymphoma
Lymphoma is a type of blood cancer that develops from lymphocytes (a type of white blood cell). It has many subtypes. A rare subtype, called intravascular large B-cell lymphoma (or IVLBCL) is notably hard to diagnose accurately because the cancerous lymphocytes grow inside small blood vessels, instead of at lymph nodes, and there is no...