Peer-Reviewed PublicationMedical Research Council (MRC) Laboratory of Medical Sciences video: A single molecule of DNA (not directly visible) is captured using microscopic beads (the large circles). Each of the red, green or yellow dots moving between the beads represent a FANCD2I-FANCI protein complex sliding along the DNA molecule, monitoring it for damage. Credit: MRC Laboratory...
By Kristen Rogers, CNN | Posted – June 27, 2023 at 6:49 a.m. ATLANTA — Radiation from nail dryers may damage DNA and lead to cancer-causing mutations in human cells, a study has found — and that might have you wondering whether your regular gel mani-pedi is worth the risk. Some dermatologists say the findings,...
by Impact Journals LLC Figure 6: LP-284 is selectively lethal in cells with TC-NER deficiency. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28454 A new research paper titled “LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin’s lymphoma models and in cells deficient in DNA damage repair” has been published in Oncotarget. Despite advances in therapies treating non-Hodgkin’s lymphoma (NHL),...
INSTITUTE FOR BASIC SCIENCE IMAGE: DSB REPAIR BY SMARCAD1, MSH2, AND EXO1. CREDIT: INSTITUTE FOR BASIC SCIENCE DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals. As DNA is a molecule...
by Keck School of Medicine of USC Credit: Pixabay/CC0 Public Domain E-cigarettes—used regularly by more than 10% of U.S. teens and more than 3% of adults—were once pitched as a healthy alternative to tobacco cigarettes. But research increasingly links the use of e-cigarettes, or vaping, to many of the same life-threatening diseases that plague smokers. In a breakthrough...
by Bob Yirka, Medical Xpress Human gut microbes isolated from IBD patients produce small-molecule genotoxins. Diverse gut microbes isolated from patients with IBD exhibit direct genotoxicity. M. morganii produces a family of genotoxic small molecule metabolites, termed the indolimines. Indolimine-producing M. morganii induces DNA damage in intestinal epithelial cells (IECs) and increased colon tumor burdens...
KYOTO UNIVERSITY Even on a good day, DNA is constantly getting damaged. Nicks, scratches, breaks the delicate strands that carry life’s genetic code take a beating as they jumble about in the course of their work. If left untreated, errors accumulate, with fatal consequences — such as cancerous tumors — for the cell and the...
Genetic screening for prostate cancer in GP surgeries could be effective at picking up otherwise undiagnosed cases of the disease, a new pilot study shows. Researchers ‘barcoded’ men for their genetic risk of prostate cancer by testing each for 130 DNA changes – and gave those at higher risk follow-up checks. Their study found that...
by Huntsman Cancer Institute To visualize LEM2’s role in mitosis, the Ullman Lab used colored fluorescent markers to label the different components: LEM2, the fibers, and the DNA. Credit: Huntsman Cancer Institute To replace aging and worn cells, the body primarily uses a process called mitosis, in which one cell divides into two. When a...
The size of the contribution of stochastic nuclear DNA damage to aging is debated. It causes cancer, when rare combinations of cancerous mutations occur and suppression of those early cancerous cells fails, but can it give rise to a meaningful degree of tissue dysfunction otherwise? The present consensus is that most such damage is irrelevant,...
