by The Mount Sinai Hospital Credit: Pixabay/CC0 Public Domain Mount Sinai researchers have published a study in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association that sheds new light on the role of DNA methylation in Alzheimer’s disease (AD). The study found that DNA methylation has a profound impact on gene and protein co-expression networks associated with AD...
by Chinese Academy of Sciences Guadecitabine (SGI-110), a DNA methyltransferase inhibitor, showed therapeutic effects in T24 and UMUC-3 cells. A, B Cell migration capacity with or without SGI-110 treatment was evaluated through wound healing assays. Values are the mean ± SD of eight independent experiments. C, D Cell invasion capacity with or without SGI-110 treatment...
by Kumamoto University (Left) The number of hypermethylated DNA regions in both neuronal and non-neuronal cells is reduced in the bipolar patient group (BD) compared to the healthy group (CT). (Right) Methylation status of the BDNF (brain-derived neurotrophic factor) receptor gene (NTRK2), which is important for mental and neurological functions. The upper panel shows the hypermethylated...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE IMAGE: Gang Fang, PhD, Associate Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai CREDIT: MOUNT SINAI HEALTH SYSTEM Journal Name: Nature Methods Title of the Article: Discovering multiple types of DNA methylation from individual bacteria and microbiome using nanopore sequencing Corresponding Author: Gang Fang,...
Toward an era where aging can be controlled KUMAMOTO UNIVERSITY THE HUMAN BODY AND THE CELLS THAT MAKE IT UP HAVE A “PROGRAM ” FOR AGING. IT IS THOUGHT THAT THERE IS AN ACCUMULATION OF SENESCENT CELLS IN TISSUES AND ORGANS… view more CREDIT: PROFESSOR MITSUYOSHI NAKAO Researchers from Kumamoto University in Japan have used...
OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER COLUMBUS, Ohio – The findings of a new study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) could refine an important set of prognostic and treatment recommendations for younger adult patients...
by University of California – San Diego An international team of researchers has developed a non-invasive blood test that can detect whether an individual has one of five common types of cancers, four years before the condition can be diagnosed with current methods. The test detects stomach, esophageal, colorectal, lung and liver cancer. Called PanSeer,...
New data show how early episodes of hyperglycemia can have long-term effects CITY OF HOPE CITY OF HOPE’S RAMA NATARAJAN, PH.D., THE NATIONAL BUSINESS PRODUCTS INDUSTRY PROFESSOR IN DIABETES RESEARCH, view more CREDIT: CITY OF HOPE DUARTE, Calif. — For people with diabetes, vascular complications like kidney disease and atherosclerosis, which can lead to poor...
May 5, 2020 — A study just released by Columbia University Mailman School of Public Health is reporting a blood-DNA-methylation measure that is sensitive to variation in the pace of biological aging among individuals born the same year. The tool – DunedinPoAm — offers a unique measurement for intervention trials and natural experiment studies investigating...
Neural progenitors cells differentiated from human embryonic stem cells. Northwestern Medicine scientists have discovered how the process of DNA methylation regulates the development of spinal cord motor neurons, according to a study published in the journal Cell Stem Cell. DNA methylation, an epigenetic mechanism that determines whether or not a gene is expressed, guides stem...
