by Gina Wadas, Johns Hopkins University Fig. 1. Ten nucleotide ssDNA-amphiphiles form parallel G-quadruplexes and self-assemble into hollow nanotubes.(A) Chemical structures of the 10-nt ssDNA-amphiphiles. (B) CD spectra in Milli-Q water and PBS of the free 10-nt ssDNA and the ssDNA-amphiphiles. (C) Schematic representation of the nanotubes and the ssDNA-amphiphiles in the nanotubes, not drawn to...
Assistant Professor Rebecca Schulman, left, and postdoctoral fellow Abdul Mohammed used this single-molecule fluorescence microscope to track the nanotube bridge formation process. In a microscopic feat that resembled a high-wire circus act, Johns Hopkins researchers have coaxed DNA nanotubes to assemble themselves into bridge-like structures arched between two molecular landmarks on the surface of a...
