September 27, 2024 by McMaster University A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body...
Tag: <span>DNA repair</span>
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New research advances understanding of DNA repair
by Audrey Post, Florida State University Zucai Suo, Eminent Professor in the Department of Biomedical Sciences, Florida State University College of Medicine. Credit: FSU College of Medicine A Florida State University College of Medicine researcher has made a discovery that alters our understanding of how the body’s DNA repair process works and may lead to...
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Study illustrates links between DNA repair and a rare neurodegenerative disease
by The Francis Crick Institute A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI Researchers at the Francis Crick Institute have pieced together genetic and molecular changes that lead to a rare progressive neurodegenerative condition called ataxia...
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Linkage confirmed between altered DNA repair, damage in neurodegenerative conditions causing movement disorders
by University of California, Irvine Increased DNA damage in neurons from SCA7 patients. Skin cells from an SCA7 patient and an unaffected sibling (WT), generated induced pluripotent stem cells. Those stem cells were used to make neurons which were grown in culture. Illustrated here are stained neurons with Hoechst to show the nucleus, and with...
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Princeton-led study of DNA repair boosts prospects for gene editing technology
PRINCETON UNIVERSITY IMAGE: A NEW TOOL CALLED REPAIR-SEQ (MAGNIFYING GLASS) ALLOWS RESEARCHERS TO QUICKLY SEE HOW DIFFERENT GENES INVOLVED IN REPAIR OF DNA DAMAGE (AMBULANCES) AFFECT THE ACCURACY AND EFFICIENCY OF GENOME EDITING TECHNOLOGIES—IN THIS CASE, ONE THAT WORKS BY FIRST CAUSING A DOUBLE-STRANDED DNA BREAK. CREDIT: CAITLIN SEDWICK FOR PRINCETON UNIVERSITY The ability to...
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CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) IMAGE: THE DIRECTOR OF THE STUDY, JUAN MÉNDEZ, IN THE CENTER, TOGETHER WITH THE RESEARCHERS ELENA BLANCO-ROMERO, ON THE LEFT, AND PATRICIA UBIETO-CAPELLA, ON THE RIGHT. /CNIO CREDIT: CNIO Chemotherapy kills tumor cells by causing damage to them. One of the most effective ways of causing damage is to...
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Insights into the role of DNA repair and Huntington’s disease gene mutation open new avenues for drug discovery
IOS PRESS IMAGE: TIMELINE OF SOME OF THE KEY EVENTS ESTABLISHING ANTICIPATION AS A GENUINE BIOLOGICAL PHENOMENON AND SOMATIC EXPANSION AS CONTRIBUTING TOWARD HUNTINGTON’S DISEASE PATHOLOGY. CREDIT: : DARREN G. MONCKTON IN “THE CONTRIBUTION OF SOMATIC EXPANSION OF THE CAG REPEAT TO SYMPTOMATIC DEVELOPMENT IN HUNTINGTON’S DISEASE: A HISTORICAL PERSPECTIVE, ” JOURNAL OF HUNTINGTON’S DISEASE...
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Tumor cells reveal a core syncytial drive to evade host defenses
by John Hewitt , Medical Xpress Credit: CC0 Public Domain Toxins, radiation, and normal metabolic processes together generate molecular lesions in every one of our cells to the tune of 10,000 to 1,000,000 hits per day. Fortunately, most of these code faults are immediately patched up by sophisticated DNA repair mechanisms. Any undetected damage to...
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Blocking DNA repair enzyme could help treat certain cancers
by The Francis Crick Institute Images showing tumours developing in the stomach and spleen of mice in the presence of ALC1 but not in the mice without ALC1. Credit: The Francis Crick Institute Researchers at the Francis Crick Institute have found a new way to prevent some tumors from repairing their own DNA, a function that...
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DNA repair supports brain cognitive development
by Osaka University Polβ deficiency influences postnatal neuronal differentiation and subsequent learning and memory in adulthood. It’s a fact of life that things break down. And when they do, whether it’s your car, the roof, or a blocked artery, there are people who we can call to help with the repairs. A lesser known fact of...
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