All life depends upon DNA repair and replication. In every human cell the essential ability to replicate and repair genomes depends upon the coordinated actions of the genome sequence. Flaws or mistakes in repair and cell cycle regulation can lead to defects in the structure of the DNA and can prevent the replication from functioning...
by Institute of Cancer Research A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial—highlighting the potential of a new class of drugs known as ATR inhibitors. The drug candidate, tested in humans for the first time, was shown to be well tolerated and stopped the growth of...
By Rachel Schraer Health reporter A drug that could stop cancer cells repairing themselves has shown early signs of working. More than half of the 40 patients given berzosertib had the growth of their tumours halted. Berzosertib was even more effective when given alongside chemotherapy, the trial run by the Institute of Cancer Research (ICR)...
Prostate cancer therapies have shown significant advances during the past decade, with multiple new therapies being introduced for patients with advanced disease. Now, the early results of a clinical trial published in the New England Journal of Medicine (NEJM) reveals for the first time that therapies based on tumor genetics – specifically DNA repair defects...
Findings open opportunities to target RUNX-deficient cancers such as breast cancer and leukemia NATIONAL UNIVERSITY OF SINGAPORE A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) pathway. IMAGE: A RESEARCH TEAM FROM THE CANCER...
The findings revealed that a special group of genes that function within the body’s normal DNA repair process were vital to the effectiveness of p53. This new information could help doctors to better identify patients with an increased risk of developing certain cancers. It could also help to develop safer, more effective treatments for patients....
Japanese researchers from Osaka University have uncovered a way in which our cells regulate the repair of broken DNA. Their results, published in the journal “Cell Reports,” show a common molecule regulates multiple repair mechanisms and help shed light on how the cell maintains the integrity of the human genome when it is damaged. The...
(From left) Dr. Ziying Liu, Keun Woo Ryu, Dr. W. Lee Kraus, and Dr. Xin Luo led research studies that focused on how PARP enzymes function. A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new...
