An imaging method reveals various proteins (blue, yellow and magenta) inside the nucleus of a human connective-tissue cell.Credit: Ajay Labade, Zachary Chiang, Caroline Comenho and Jason Buenrostro Researchers are queuing up to try a powerful microscopy technique that can simultaneously sequence an individual cell’s DNA and pinpoint the location of its proteins with high resolution...
Tag: <span>DNA sequence</span>
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‘Bad’ cholesterol gene silenced without altering the DNA sequence
By Paul McClure Epigenetic editing has been used to silence a cholesterol-regulating gene in miceAI-generated by DALL-E By silencing the gene responsible for regulating ‘bad’ cholesterol without altering the primary DNA sequence, researchers have shown that it’s possible to use epigenetic editing to treat diseases rather than conventional DNA-breaking gene editing technology, which risks unintended effects....
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The beginning is the end
MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS IMAGE: EXAMPLE OF A GENE THAT CONTAINS TWO POSSIBLE START SITES (TSS), AND TWO POSSIBLE END SITES (TES). BLACK BOXES IN THE GENE MODEL SHOW SEQUENCES THAT WILL BE TRANSLATED INTO PROTEIN. WITH CONVENTIONAL SHORT-READ MRNA SEQUENCING, IN WHICH SIGNAL REPRESENTS THE ACCUMULATION OF READS, IT IS NOT...