by University of Sheffield TEX264 acts at replication forks. Credit: Nature Communications (2020). DOI: 10.1038/s41467-020-15000-w A new “toolkit” to repair damaged DNA that can lead to aging, cancer and motor neuron disease (MND) has been discovered by scientists at the Universities of Sheffield and Oxford. Published in Nature Communications, the research shows that a protein called TEX264, together with other...
Tag: <span>DNA</span>
Post
DNA sequencing reveals significant decrease in gut bacterial diversity during aging
by Agency for Science, Technology and Research (A*STAR), Singapore Aging-associated shifts in gut microbiome richness and relative abundance of key species. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52097-9 A new study has revealed that gut bacteria may play a key role in aging, and that specific microbes could be targeted to promote healthy aging. ADVERTISING The Nature Communications study was conducted...
Post
New CRISPR system for gene silencing doesn’t rely on cutting DNA
by Vilnius University The final model of the type IV-A mechanism. From left to right: Step 1 shows the formation of the “effector” complex, consisting of guide RNA and type IV-A proteins (rendered from a cryo-EM structure). The RNA-protein complex binds to a short motif next to the DNA target site (PAM). In Step 2, an...
Post
DNA packaging directly affects how fast DNA is copied in cells, scientists discover
by Hubrecht Institute Credit: Pixabay/CC0 Public Domain Researchers from the Mattiroli group have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. This opens up...
Post
Study links sequence variants to DNA methylation and diseases
JULY 24, 2024 by deCODE genetics Credit: Pixabay/CC0 Public DomainA new study by scientists at deCODE Genetics shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and other human traits. The research is published in the journal Nature Genetics under the title “The...
Post
New class of cancer mutations discovered in so-called ‘junk’ DNA
JULY 3, 2024 by Garvan Institute of Medical Research Visualized DNA damage (green) in human breast cancer cells (blue). Credit: Garvan InstituteUsing artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called ‘junk’ regions of DNA, opening up possibilities for a new approach to diagnosis and treatment. Non-coding DNA—the 98% of our...
Post
When is genome sequencing advisable?
NEWS RELEASE 10-JUN-2024 When is genome sequencing advisable? Peer-Reviewed PublicationUNIVERSITÄT LEIPZIG Genetic mutations in human DNA can prevent proteins that perform important functions in the body from being formed correctly. This can lead to serious disorders that cause disease or even disability. Many of these diseases are already known and can be attributed to specific...
Post
Detecting pathogens faster and more accurately by melting DNA
by Ioana Patringenaru, University of California – San Diego Researchers use this chip to analyze the microbes present in whole blood samples. Credit: David Baillot/University of California San DiegoA new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis....
Post
DNA Origami Folded Into My Tiny Motor
According to research published in the journal Nature Nanotechnology, scientists have created the world’s first working nanoscale electromotor. The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created the world’s first working nanoscale electomotor....
Post
Scientists on the brink of cure for heart disease – with drugs that ALTER your DNA
Are we on the brink of a cure for heart disease? That was the question being whispered by normally cautious cardiologists at the American Heart Association annual conference in Philadelphia last week. Over three packed days, a raft of game-changing scientific discoveries have been unveiled by the world’s leading specialists – many of which will...