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Investigators discover a ‘double life’ for a key Parkinson’s disease protein
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Investigators discover a ‘double life’ for a key Parkinson’s disease protein

by Brigham and Women’s Hospital A graphic depicts the “two faces of alpha-synuclein” and the transition from normal states (upper, organized molecular machines on a well-defined grid) to pathologic states in which there is membrane disruption, altered protein interactions and localization (lower, chaotic, disrupted machines, darker tone). Credit: Gergana Petrova. One of the hallmarks of...