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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

by Massachusetts Institute of Technology Neural progenitor cells with the typical number of chromosomes show significant outward migration in culture (top). The culture in the bottom left shows untreated trisomy 21 cells. On the bottom right are cells treated with anti-senescence drugs, which restored migration. Credit: Alana Down Syndrome Center at MIT In Down syndrome,...