Minuscule Robots for Targeted Drug Delivery December 11, 2024 In the future, delivering therapeutic drugs exactly where they are needed within the body could be the task of miniature robots. Not little metal humanoid or even bio-mimicking robots; think instead of tiny bubble-like spheres. Such robots would have a long and challenging list of requirements....
Tag: <span>Drug delivery</span>
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Study shows cholesterol enhances exosome-mediated RNA drug delivery
September 20, 2024 by Liu Jia, Chinese Academy of Sciences Cholesterol-enriched exosomes merged with the cell surface. Credit: Gan’s labRNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short...
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Russian doll’ packaging developed at Imperial could boost drug delivery
News Release 29-Jul-2024 Peer-Reviewed PublicationImperial College London The new technology, which is in the early stages of development, has the potential to significantly enhance the effectiveness and reduce the side effects of drugs and vaccines. Drugs and vaccines can be delivered to the body using tiny packages called nanoparticles. The structures of these delivery particles...
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Light-activated molecular motor drives drug delivery
BY JAMES URQUHART 11 JULY 2023 A new drug delivery technique uses synthetic molecular motors to release a drug when activated by visible light. The proof-of-principle delivery mechanism, which was tested on cultured lung cancer cells, could enable a non-invasive, highly controlled and targeted way to activate drugs inside the body. Ben Feringa at the University...
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Magnetic microrobots with folate targeting for drug delivery
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: THE INTRODUCTION OF FA IMPROVED THE TUMOR TARGETING ABILITY OF THE MICROROBOTS, WHICH CAN BE MANIPULATED BY MAGNETIC FIELDS, PRODUCING AN OBVIOUS ANTICANCER EFFECT. CREDIT: CYBORG AND BIONIC SYSTEMS The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this,...
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A promising drug delivery method could replace injections with pills
by Baylor College of Medicine Credit: CC0 Public Domain For chronic conditions such as rheumatoid arthritis, treatment often involves lifelong injections. Fear of needles, injection-associated infection and pain are responsible for patients skipping doses, which encourages the development of new delivery strategies that combine efficacy with limited side effects to treat patients adequately. Researchers at Baylor...
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Biological lasso: Enhanced drug delivery to the brain
KANAZAWA UNIVERSITY IMAGE: © 2022 SAKAI, ET AL. (A) A PHARMACOPHORE SEQUENCE OF MET RECEPTOR-BINDING MACROCYCLIC PEPTIDE (AMD4; SHOWN IN RED) WAS INSERTED INTO THE LOOPS (COLOURED BALLS) OF HUMAN IGG1 FC PROTEIN. (B) LASSO-GRAFTING FC YIELDS MET AGONISTS WITH EXTENDED HALF-LIFE IN THE BODY. (C) LASSO-GRAFTING FC OF AN ANTI-TFR ANTIBODY YIELDS MET AGONISTS...
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Drug delivery technology enhances absorption of widely used opioid replacement therapy
by Monash University The main metabolism pathway and metabolites of BUP, including norbuprenorphine, norbuprenorphine glucuronide, and buprenorphine glucuronide. Credit: Frontiers in Pharmacology (2022). DOI: 10.3389/fphar.2022.879660 Monash University researchers have harnessed a new drug delivery technology to allow the oral administration of buprenorphine (BUP), a drug used for severe pain management and opioid replacement therapy. At present BUP...
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Tiny biohybrid robots for intelligent drug delivery
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: SCIENTISTS FROM BEIJING INSTITUTE OF TECHNOLOGY REVIEWED PROGRESS AND PERSPECTIVES OF BIOHYBRID MICRO- AND NANOROBOTS FOR INTELLIGENT DRUG DELIVERY. CREDIT: JINHUA LI, BEIJING INSTITUTE OF TECHNOLOGY A review paper by scientists at the Beijing Institute of Technology summarized recent advancements in use of intelligent biohybrid micro- and...
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Innovative drug delivery system offers hope for treating genetic diseases
HARVARD UNIVERSITY IMAGE: POSTDOCTORAL FELLOW SAMAGYA BANSKOTA (LEFT) AND GRADUATE STUDENT ADITYA RAGURAM (RIGHT), CO-LEAD AUTHORS, INVESTIGATE IN VIVO DELIVERY OF THERAPEUTIC PROTEINS AT THE LIU LAB. CREDIT: JULIA MCCREARY/ HARVARD GRADUATE STUDENT. A team of researchers led by Harvard and Broad Institute scientists has developed a new drug delivery system using engineered DNA-free virus-like...
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