Peer-Reviewed Publication ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE GRAPHICAL ABSTRACT OF CYCLIC ORAL PEPTIDES. CREDIT: CHRISTIAN HEINIS/EPFL For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular protein homologs. Typically,...
by Cincinnati Children’s Hospital Medical Center Human intestine organoids growing in wells of a lab dish as part of a study at Cincinnati Children’s demonstrating a new mass production method for gut organoids. Credit: Cincinnati Children’s As the idea of growing tiny human organs in lab dishes has moved in recent years from futuristic science...
KAROLINSKA INSTITUTET Researchers at Karolinska Institutet and SciLifeLab in Sweden describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function. Their innovative technique can lead to improved drugs for diseases involving oxidative stress, such as cancer, Alzheimer’s disease and lung...
by Queen Mary, University of London Credit: CC0 Public Domain New research from Queen Mary University of London, published in Nature Medicine, has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug treatments will work to treat rheumatoid arthritis (RA) patients. The researchers also identified specific genes associated with resistance...
by Griffith University The three-dimensional structure of the SARM1 protein determined by cryo-electron microscopy. Credit: Jeff Nanson. A Griffith University-led research team has discovered how a therapeutic target common among debilitating neurodegenerative disorders is activated, which could help accelerate drug development. In a study published in the journal Neuron, the researchers from Griffith University’s Institute for Glycomics, the...
Posted Today Methotrexate and the more expensive mycophenolate mofetil performed similarly in a head-to-head clinical trial that compared the two drugs for treating noninfectious uveitis, an eye disease that accounts for up to 15% of blindness in the U. S. In cases of more severe disease, posterior uveitis and panuveitis, the international trial showed that...
by University of Pittsburgh Over the course of a decade, out-of-pocket costs for multiple sclerosis drugs rose more than sevenfold for Medicare Part D beneficiaries, according to a JAMA Neurology study published today by researchers at the University of Pittsburgh. Using Medicare claims data from 2006-2016, the researchers looked at trends in multiple sclerosis drug...
Posted Today Andrew Fraser did not set out to study parasites, but when his team stumbled on an intriguing finding he could not look away. Fraser’s team at the University of Toronto was testing a new method for unpicking how drugs affect the movement of a non-parasitic nematode, Caenorhabditis elegans (C. elegans), which is used as a stand-in for humans A chance...
Image caption Developing new drugs to fight major diseases can take years and cost billions of dollars Technology of Business Has the time now come for internet voting? Facebook’s tentacles reach further than you think How Cuba’s growing internet is fuelling new businesses How DNA-testing kits are becoming big business Developing a drug from a promising...
A team of researchers from Case Western Reserve University School of Medicine has helped uncover the elusive structure of a cancer cell receptor protein that can be leveraged to fight disease progression. Previous studies have showed blocking the receptor can slow tumor growth and metastasis in certain cases. However, the development of drugs (inhibitors) has...
