NOVEMBER 17TH, 2023POSTED BY LESLIE ORR-ROCHESTER In mice and in tissue studies, when researchers suppressed Netrin-1 with the anti-cancer drug (NP137), cancer was less likely to spread and cancer cell death occurred. (Credit: Getty Images) Laboratory findings have set the stage for a clinical trial investigating a drug for pancreatic cancer that has spread to the liver....
Tag: <span>Drug Discovery</span>
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Common chemotherapy drugs don’t work like doctors thought, with big implications for drug discovery
by Will Cushman, University of Wisconsin-Madison A cancer cell undergoing abnormal mitosis and dividing into three new cells rather than two following treatment with a microtubule poison. Credit: Beth Weaver, University of Wisconsin–Madison A new study from the University of Wisconsin–Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and...
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New model offers a way to speed up drug discovery
MASSACHUSETTS INSTITUTE OF TECHNOLOGY IMAGE: BY APPLYING A LANGUAGE MODEL TO PROTEIN-DRUG INTERACTIONS, RESEARCHERS CAN QUICKLY SCREEN LARGE LIBRARIES OF POTENTIAL DRUG COMPOUNDS. CREDIT: ISTOCK CAMBRIDGE, MA — Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease. Ideally, scientists would like to experimentally test each...
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A human interactome to prioritise drug discovery
EUROPEAN MOLECULAR BIOLOGY LABORATORY IMAGE: A HUMAN INTERACTOME TO PRIORITISE DRUG DISCOVERY CREDIT: KAREN ARNOTT/EMBL-EBI Scientists at Open Targets, EMBL’s European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins. By helping to understand how biological processes affect human traits and diseases, this work will...
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Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat
SCRIPPS RESEARCH INSTITUTE IMAGE: ZAFIRLUKAST INDUCES THE PRODUCTION OF BROWN ADIPOCYTE TISSUE. FOR PREADIPOCYTES TREATED WITH ZAFIRLUKAST (RIGHT IMAGE), BROWN ADIPOCYTES (SHOWN IN RED) WERE MUCH MORE PREVALENT THAN PREADIPOCYTES GROWN WITH THE DMSO CONTROL (LEFT IMAGE). CREDIT: SCRIPPS RESEARCH AND CALIBR LA JOLLA, CA— “Metabolism” describes the body’s chemical changes that create the necessary materials...
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Drug discovery approach reveals why drugs for cystic fibrosis fall short
by The Scripps Research Institute Scripps researchers analyzed many genetic variants associated with cystic fibrosis across the population to determine how the CFTR protein’s functional structure changes with disease and therapeutics. Credit: Scripps Research To cure rare genetic diseases, from cystic fibrosis to Niemann-Pick, scientists at Scripps Research have turned to a computational approach usually...
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An Example of Senomorphic Drug Discovery
Senescent cell accumulation is a feature of aging, a growing imbalance between the rate of creation and rate of destruction. Senescent cells perform a number of useful tasks in the short-term, but when present for the long-term, their inflammatory secretions disrupt tissue function and contribute meaningfully to the onset and progression of age-related disease. A great many research...
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Artificial intelligence could be new blueprint for precision drug discovery
by Scott Lafee, University of California – San Diego Credit: CC0 Public Domain Writing in the July 12, 2021, online issue of Nature Communications, researchers at the University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely...
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In vivo drug discovery for β-cell proliferation in diabetes
by Karolinska Institutet Credit: Unsplash/CC0 Public Domain In a study published in Nature Metabolism, researchers at the department of Cell and Molecular Biology developed a novel technique to identify small molecules that can make insulin-producing β-cells divide. Olov Andersson and Jeremie Charbord explains: “Diabetes is characterized by the progressive loss of functional β-cells. One possible approach to curing diabetes...
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Insights into the role of DNA repair and Huntington’s disease gene mutation open new avenues for drug discovery
IOS PRESS IMAGE: TIMELINE OF SOME OF THE KEY EVENTS ESTABLISHING ANTICIPATION AS A GENUINE BIOLOGICAL PHENOMENON AND SOMATIC EXPANSION AS CONTRIBUTING TOWARD HUNTINGTON’S DISEASE PATHOLOGY. CREDIT: : DARREN G. MONCKTON IN “THE CONTRIBUTION OF SOMATIC EXPANSION OF THE CAG REPEAT TO SYMPTOMATIC DEVELOPMENT IN HUNTINGTON’S DISEASE: A HISTORICAL PERSPECTIVE, ” JOURNAL OF HUNTINGTON’S DISEASE...
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