Gayle N. Scott, PharmD DISCLOSURES June 18, 2019 Lab tests play a key role in clinical decision-making. More than 4000 lab testsare available, and an estimated 70% of clinical decisions are based on their results. Correct interpretation is critical. The pharmacologic effects of drugs can change the results of lab tests; for example, levothyroxine increases thyroid levels, or lisinopril may increase potassium levels. But these changes do not involve...
Tag: <span>drug interactions</span>
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Drug interaction causes hypotension
by Leigh Macmillan, Vanderbilt University The commonly used muscle relaxant tizanidine can lower blood pressure. Tizanidine is metabolized by the enzyme CYP1A2, and concurrent use of tizanidine and a CYP1A2 inhibitor, such as ciprofloxacin, greatly increases tizanidine plasma concentrations. Despite package insert warnings, tizanidine and CYP1A2 inhibitors are commonly co-prescribed. Cecilia Chung, MD, and colleagues used...
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Six surprising drug interactions you should know about
As the UK population grows older, more and more people are using a combination of drugs to treat multiple conditions. This can lead to interactions and side effects that we all need to be aware of. Not only can drugs interact with each other, but they can also interact with food and drink, as well...
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