Findings may have far-reaching implications for the responsiveness of cancers to epigenetic therapies Peer-Reviewed Publication BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)—One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures. In cases of melanoma, the main targeted...
Tag: <span>Drug resistance</span>
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Study opens route to overcoming drug resistance in stomach cancer
by Institute of Cancer Research Stomach cancer cells. Credit: Katharina von Loga Scientists have shown how stomach cancers can dodge the effects of a promising new experimental treatment—raising the possibility of outsmarting cancer by predicting drug resistance in advance. Their new study found that stomach cancers could develop resistance to a new class of drugs...
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Drug resistance is a powerful menace in certain breast and ovarian cancers. Now scientists are figuring out why
by Delthia Ricks , Medical Xpress Credit: Unsplash/CC0 Public Domain Just as bacteria, viruses and fungi develop strategies to outsmart antimicrobial medications, cancer cells can become resistant to chemotherapy. And among tumors, those associated with triple negative breast cancer and ovarian tumors can develop a powerful form of resistance. In an intriguing line of research,...
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New computer simulation cracks mystery of cancer drug resistance
by University of Maryland Computer simulation methods developed by Pratyush Tiwary’s lab identified two optimum pathways that Gleevec, a cancer drug, could take to unbind from the protein. The “fast” pathway allows Gleevec to leave the protein three times faster than that of the “slow” pathway, ultimately leading to drug resistance. Credit: Pratyush Tiwary Imatinib,...
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Feedback disruptors—a new class of therapeutics—throw drug resistance for a loop
by Sarah Stanley, Gladstone Institutes Scientists at Gladstone Institutes have developed a new class of therapeutics that have the potential of transforming treatments for viral diseases. Shown here is Sonali Chaturvedi, first author of the study. Credit: Michael Short/Gladstone Institutes Viruses in the herpesvirus family are leading causes of birth defects, blindness, and failed organ...
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Breakthrough in overcoming drug resistance provides new hope for blood cancer patients
by University of South Australia Credit: Pixabay/CC0 Public Domain South Australian scientists have made a significant breakthrough in overcoming drug resistance in acute myeloid leukemia (AML), a rare and devastating blood cancer that kills most patients within a few years. In a new study published in the hematology journal Blood, researchers from UniSA and SA Pathology’s...
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Rewiring the biology of leukemia cells to reverse drug resistance
by Queen Mary, University of London Credit: Unsplash/CC0 Public Domain Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells. By rewiring the inner workings of the cancer cells, the team was able prime...
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Targeting ‘cell clustering’ by gene deletion reduces drug resistance
by Stony Brook University Image of clustering yeast cells and yeast cells separated after removal of the AMN1 gene. Credit: Gábor Balázsi A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer. Led...
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‘Host-directed therapy’ could treat infectious diseases—including COVID—and limit drug-resistance
by Christian Doerig, Genia Burchall, Jack Adderley and Tayla Williamson, The Conversation Credit: Shutterstock Antibiotics, together with antivirals and anti-parasitic drugs, can save the lives of people who’ve contracted an infectious disease. But the rise of drug-resistance means new strategies are needed. At the end of last year, the World Health Organization declared antimicrobial resistance one of...
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Protein structure offers clues to drug-resistance mechanism
MASSACHUSETTS INSTITUTE OF TECHNOLOGY IMAGE: MIT CHEMISTS HAVE DISCOVERED HOW THE STRUCTURE OF THE EMRE TRANSPORTER CHANGES AS A COMPOUND MOVES THROUGH IT. AT LEFT IS THE TRANSPORTER STRUCTURE AT HIGH PH. AS THE PH DROPS (RIGHT), THE HELICES BEGIN TO TILT SO THAT THE CHANNEL IS MORE OPEN TOWARD THE OUTSIDE OF THE CELL,...