Tag: <span>Drug resistance</span>

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Researchers discover mechanism to overcome drug-resistance in leukemia
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Researchers discover mechanism to overcome drug-resistance in leukemia

by  Yale University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published...

New drug that can prevent the drug resistance and adverse effects
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New drug that can prevent the drug resistance and adverse effects

NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY IMAGE: THIS CANCER CELL SPECIFIC ANTI-CANCER DRUG PRECURSOR (SMAC-FRG-DOX) FORMED ITSELF BY HYDROPHOBIC INTERACTION WITHIN THE MOLECULE WITHOUT THE USE OF ADDITIONAL POLYMERS AND DRUG CARRIERS. Although the diverse treatment methods developed to effectively treat cancer, chemotherapy using anticancer agents has been proven especially effective in many clinical applications. Above...

NTU develops peptide that makes drug-resistant bacteria sensitive to antibiotics again
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NTU develops peptide that makes drug-resistant bacteria sensitive to antibiotics again

Peptide also kills multidrug-resistant bacteria on its own NANYANG TECHNOLOGICAL UNIVERSITY SCIENTISTS AT NTU HAVE DEVELOPED A SYNTHETIC ANTIMICROBIAL PEPTIDE THAT MAKES DRUG-RESISTANT BACTERIA SENSITIVE TO ANTIBIOTICS AGAIN. ON ITS OWN, THE PEPTIDE CAN ALSO KILL BACTERIA THAT HAVE GROWN RESISTANT… view more CREDIT: NTU SINGAPORE Scientists at Nanyang Technological University, Singapore (NTU Singapore) have...

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Portable, reusable coronavirus sensor produces results within a minute

Reviewed by Emily Henderson, B.Sc “Testing, testing, testing.” It’s a mantra that health officials have been constantly promoting because screening people for COVID-19 is the best way to contain its spread. In the U.S., however, that crucial necessity has been hampered due to a lack of supplies. But University of Utah electrical and computer engineering...

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Scientists tackle potential drug resistance by using new single-cell genetic method

UNIVERSITY OF NOTRE DAME Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor’s potential resistance to a drug, and then identified a drug combination that reversed that resistance. Siyuan Zhang, the Dee Associate Professor of Biological Sciences at Notre Dame, and his...

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SOME WATER DISINFECTION MISSES DRUG-RESISTANT GENES

POSTED BY SARAH MCQUATE-WASHINGTON Huan He examines how well bacteria grew on agar plates containing an antibiotic. (Credit: Mark Stone/U. Washington) Current water and wastewater disinfecting methods work well to deter bacterial growth, but have varied success in fighting an antibiotic resistance gene, according to new research. Each year, antibiotic-resistant bacteria infect at least 2 million...

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Sensitive tests suggest low risk of drug resistance with dapivirine ring

New results presented at HIVR4P finds no dapivirine-associated resistance detected among women who acquired HIV while using dapivirine vaginal ring in ASPIRE MICROBICIDE TRIALS NETWORK MADRID, October 24, 2018 – A monthly vaginal ring that slowly releases an antiretroviral (ARV) drug called dapivirine is currently undergoing regulatory review. If approved, the dapivirine ring would be the first biomedical HIV prevention method developed...

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Drug sensitivity and resistance testing could make ‘right to try’ a real thing

The contentious “right to try” bill that President Trump signed into law to help terminally ill patients get access to treatments that might — I emphasize the “might” — cure them or prolong their lives is more wishful thinking that it is a reality. Human HeLa cells in culture. Recent advances in drug sensitivity and resistance testing suggest that it’s worth...

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Compound scores key win in battle against antibiotic resistance

Researchers at Oregon State University have made a key advance in the fight against drug resistance, crafting a compound that genetically neutralizes a widespread bacterial pathogen’s ability to thwart antibiotics. The findings are important because antibiotic resistance is a growing global threat, with the percentage of isolates with multidrug resistance on the rise for many...