HOKKAIDO UNIVERSITY IMAGE: THE SPHAERIMICIN ANALOGS (SPMS) INHIBIT THE ACTIVITY OF MRAY, AND HENCE THE REPLICATION OF BACTERIA, WITH DIFFERENT DEGREES OF EFFECTIVENESS. THE POTENCY OF THE ANALOG INCREASES AS THE IC50 DECREASES (TAKESHI NAKAYA, ET AL. NATURE COMMUNICATIONS. DECEMBER 20, 2022). CREDIT: (TAKESHI NAKAYA, ET AL. NATURE COMMUNICATIONS. DECEMBER 20, 2022) Researchers have designed...
AMERICAN CHEMICAL SOCIETY Urinary tract infections are common, yet are increasingly tough to treat because the bacteria that cause them are becoming resistant to many antibiotics. Now, in ACS Central Science, researchers report a new molecule that inhibits drug-resistant bacteria in lab experiments, as well as in mice with pneumonia and urinary tract infections. The researchers...
Researchers have discovered how Gram-negative bacteria—which cause drug-resistant pneumonia, bloodstream infections, and surgical site infections in hospitalized patients—finish building a crucial component of their outer membrane that shields these pathogens from attacks by the immune system and antibiotics. The new findings could accelerate the development of novel drugs to counteract these potentially deadly bacteria, the...
by Bob Yirka, Medical Xpress Relevant genomic and proreomic characteristics of phage M1. Genome representation of phage M1 and comparison, using a BLASTn analysis, with Slopekvirus type species KP15 (a). Each white or colored arrow represents a predicted open reading frame. In orange, genes encoding packaging and lysis-associated proteins are displayed, in yellow structural proteins...
KTH, ROYAL INSTITUTE OF TECHNOLOGY IMAGE: A CLOSE UP OF THE DENDRITIC HYDROGEL DEVELOPED AT KTH ROYAL INSTITUTE OF TECHNOLOGY CREDIT: MALKOCH GROUP/KTH ROYAL INSTITUTE OF TECHNOLOGY In the fight against multidrug-resistant bacteria, scientists in Sweden have developed a new kind of antibiotic-free protection for wounds that kills drug-resistant bacteria and induces the body’s own...
by Hong Kong Baptist University The cell sensor with a barcode-like micro-channel structure comprises two main parts: a cell culture zone and a “barcode” cell sensor. Credit: Hong Kong Baptist University A research team led by scientists at Hong Kong Baptist University (HKBU) has developed a novel cell sensor with a barcode-like micro-channel structure that enables rapid and...
by Steven Reinberg It’s hard to resist those big, pleading eyes in the pet store window. But buyer beware. Pet store puppies may infect people with a bacteria for which no common antibiotic treatment exists, a new study warns. Campylobacter jejuni (C jejuni) cannot be treated with any common antibiotics and is an increasing public...
UNIVERSITY OF NOTRE DAME Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor’s potential resistance to a drug, and then identified a drug combination that reversed that resistance. Siyuan Zhang, the Dee Associate Professor of Biological Sciences at Notre Dame, and his...
Pathogenic bacteria are rapidly developing resistance to the arsenal of microbial therapies—and driving researchers to identify families of therapeutics with new modes of action. Recently, those include antibiotics that inhibit LpxC, an enzyme critical to forming the outer membrane of Gram-negative bacteria. This week in mBio, an international group of scientists report on laboratory experiments suggesting...
Targeted treatment could be used for pneumonia and other bacterial infections Antibiotic resistance is a growing problem, especially among a type of bacteria that are classified as “Gram-negative.” These bacteria have two cell membranes, making it more difficult for drugs to penetrate and kill the cells. Researchers from MIT and other institutions are hoping to...
