September 23, 2024 by Delthia Ricks , Medical Xpress Model of MERTK mechanisms for regulating TGFβ core fibrotic pathway across various organs. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj0133Medical science has long been on the hunt for a deeper understanding of the devastating scarring of the body’s organs known as fibrosis, which leads to irrevocable...
by Christine Vollgraf, Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. Structured Graphical Abstract. Credit: European Heart Journal (2023). DOI: 10.1093/eurheartj/ehad086 When the heart gets out of rhythm, characteristic processes occur in the heart muscle cells. Among other things, the currents of electrically charged particles (ions) change. In chronic atrial fibrillation, one of these currents is reduced. Dr. Cristina Molina...
by University of Manchester Eczema, also known as atopic dermatitis, is a chronic condition that causes the skin to become extremely itchy. Persistent scratching can lead to redness, blisters that “weep” clear fluid, bleeding, and crusting of certain areas of the skin. People with eczema also can be more susceptible to bacterial, viral, and fungal...
by Haleigh Ehmsen, Northwestern University Response rates in all FLT3mut patients treated at any dose (n = 56) and in those who did (n = 35) or did not (n = 21) receive prior treatment with a FLT3 TKI. mCRc was defined as CR + CRi + CRp per criteria used in the ADMIRAL study. CR, complete...
KANAZAWA UNIVERSITY IMAGE: GRAPHICAL SCHEMA SHOWING THE MECHANISM FOR OVERCOMING INTRINSIC RESISTANCE TO ALK-TKIS OWING TOTP53 MUTATIONS CREDIT: KANAZAWA UNIVERSITY Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment. Alectinib is a drug commonly...
