by King’s College London Credit: Unsplash/CC0 Public DomainA drug used to treat rheumatoid arthritis could also prevent the disease in individuals deemed to be at risk. Results from a Phase 2b clinical trial, published today in The Lancet by researchers led by King’s College London, provide hope for arthritis sufferers after it was shown that the...
by University of Ottawa Multi-omic characterization of VXN cancer-selective effect on cell functions. Credit: Nature Cancer (2024). DOI: 10.1038/s43018-024-00727-yA new, cutting-edge study from the University of Ottawa (uOttawa) has found vanoxerine, a drug initially developed for the treatment of cocaine addiction, could impede advanced colorectal cancer stem cells by essentially re-wiring critical gene networks. This new...
People over 65 make up a sizable portion of Americans on GLP-1 drugs. That might be trouble. By Daniel Engber A scale overlaid with a silhouette of an older adultIllustration by Ben Kothe / The Atlantic. Sources: Peter Dazeley; JakeOlimb / Getty.Imagine an older man goes in to see his doctor. He’s 72 years old...
by Olivia Dimmer, Northwestern University Credit: Wikimedia CommonsAn experimental drug designed to block blood-clotting proteins may lower the risk of recurrent strokes, according to a dose-finding trial published in The Lancet Neurology. More than 795,000 people in the United States each year suffer a stroke, according to the American Heart Association, and nearly 1 in 5...
by University of Washington School of Medicine Credit: Pixabay/CC0 Public Domain In a clinical trial of patients with chronic kidney disease, an experimental drug significantly reduced albuminuria—albumin in urine, a sign of kidney damage—for 50% of participants. When the experimental drug was paired with a standard-care medication, 70% of participants reportedly experienced a significant reduction in...
by University of Southern California Credit: Pixabay/CC0 Public Domain Two stories dominated Alzheimer’s news this year: The FDA’s approval of Leqembi, the first drug to slow progression of the disease, and a surprising study showing that mild cognitive impairment is wildly underdiagnosed. “For mild cognitive impairment, or MCI, caused by Alzheimer’s disease, the earlier you treat...
by Emily Packer, eLife ABT263 effectively depletes endplate SnOCs in the LSI and aging mouse models.(a-c) Immunofluorescent staining of p16 (green), TRAP (red) and nuclei (DAPI; blue) of the endplates in aged (a) and LSI-mice (b) injected with PBS (control) or ABT263 and the quantitative analysis of SnOCs based on dual staining for p16 and TRAP...
F. Perry Wilson, MD, MSCEDISCLOSURES October 24, 2023 Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson of the Yale School of Medicine. As some of you may know, I do a fair amount of clinical research developing and evaluating artificial intelligence (AI) models, particularly machine learning...
Published: Jul. 09, 2023, 7:52 p.m. The injectable drug Ozempic is shown Saturday, July 1, 2023, in Houston. (AP Photo/David J. Phillip)AP By Leada Gore | [email protected] It’s typical advice given to someone undergoing a medical procedure involving general anesthesia: Don’t eat or drink anything for a period prior to the operation. Forgoing food or water is...
by University of California – San Diego Mouse pancreatic tumors were significantly smaller after being treated with a combination of KRAS inhibitor MRTX1133 and ERBB inhibitor Afatinib (bottom row), compared to no treatment (top row) or being treated with Afatinib (second row) or MRTX1133 (third and fourth rows) alone. Credit: UC San Diego Health Sciences Mutations...
