One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo, suggests new findings The research, led by scientists from Imperial College London and published in the Journal of the American Medical Association, studied three types of diabetes treatment: sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide...
Tag: <span>Drug</span>
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Researchers define target and mechanism of antibacterial drug fidaxomicin (Dificid)
Fidaxomicin (cyan) binds to RNA polymerase (gray) at the base of the clamp, a part of RNA polymerase that swings open by 17 degrees to allow RNA polymerase to bind to DNA and swings closed to allow RNA polymerase to hold onto DNA (open clamp A team of Rutgers University and international scientists have determined...
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Peptide reverses Cardiac fibrosis in a pre-clinical model of Congestive heart failure
Cardiac fibrosis: An abnormal thickening of the heart wall leading to congestive heart failure, was not only halted but also reversed by a Caveolin-1 surrogate peptide (CSD) in a preclinical model, say researchers at the Medical University of South Carolina (MUSC) in an article published online by Laboratory investigation. CSD was able to decrease the...
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Medical Marijuana
Key facts: Medical Marijuana refers to the whole plant of marijuana used for medical purposes. Cannabinoids refer to substances in cannabis that act on cells in the body to cause some effect. The 2 major ingredients in cannabinoids are Tetrahydrocannabinol (THC) & Cannabidiol (CBD). Pieces of evidence are there to prove that cannabis is helpful...
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Synthetic sugar against autoimmune diseases
Summary: Researchers are working on an innovative approach to treating a rare autoimmune disease of the peripheral nervous system, using a kind of molecular sponge made of sugar to remove pathogenic antibodies from the bloodstream. Developed to treat anti-MAG neuropathy, the approach also has potential applications in the treatment of other autoimmune diseases. AMG neuropathy:...
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Financial ties between researchers and drug industry linked to positive trial results
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ. Relationships with industry are common among investigators of randomised clinical trials (RCTs) — raising concerns about the effect that financial ties may have...