by Georgetown University Medical Center Credit: CC0 Public Domain Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results reported from the ADVANCE IV...
by Dalhousie University Thiopurines 6-thioguanine and 6-thioguanosine inhibit coronavirus replication. (A) Structures of thiopurines used this study in comparison to guanine. (B) Calu-3 cells were infected with SARS-CoV-2 at an MOI of 0.1 then treated with 6-thioguanine (6-TG), 6-thioguanosine (6-TGo), or 6-mercaptopurine (6-MP). Supernatants were harvested after 48 h and stored at -80°C until titering...
by Rockefeller University Credit: Pixabay/CC0 Public Domain As a rare and lethal liver cancer that disproportionately harms young adults, fibrolamellar carcinoma is nearly incurable. Surgery can remove the tumor, but no existing therapies are capable of reining in the cancer once it starts to spread throughout the body. Now, a new study demonstrates that fibrolamellar...
by Ian Haydon, University of Washington School of Medicine Neoleukin-2/15 can be split into two fragments that reconstitute its activity when combined. a, Splitting strategy for Neo-2/15. Structure of Neo-2/15 (cylinder representation) and murine IL-2 receptors β and γ (beige and pink surface representations, respectively, PDB ID: 6dg5). Dashed line represents the selected split site...
by Wayne Lewis, University of California, Los Angeles This chart shows levels of SARS-CoV-2 and deactivated YAP (pYAP127) in healthy cultured cells (mock) and cultured cells infected with the original strain of COVID-19 (SARS-CoV-2 Parental) and the Delta strain (SARS-CoV-2 Delta). Asterisks in the insets indicate uninfected cells. Credit: UCLA/Broad Stem Cell Research Center An...
by UT Southwestern Medical Center Colonoscopic image of mice lacking the Pak2 gene showing severe colon inflammation. Credit: UT Southwestern Medical center A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings,...
by Birgit Niesing, Deutsches Zentrum für Diabetesforschung GLP-1RA/tesaglitazar in obese GLP-1R knockout mice. a–n, Body weight (a,h), change in fat and lean tissue mass (b,c,i,j), cumulative food intake (d,k), blood glucose (e,l) and i.p. GTT (f,m) in 36-week-old male DIO wildtype (WT) (a–g) or GLP-1R knockout (KO) mice (h–n) treated for 6 days with either vehicle...
by H. Lee Moffitt Cancer Center & Research Institute Credit: Min Yu (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC),USC Norris Comprehensive Cancer Center Cells in the surrounding tumor microenvironment have a significant impact on cancer growth, survival and responses to therapy. Cancer-associated fibroblasts in the tumor environment have typically...
by American Chemical Society Credit: CC0 Public Domain Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients. But researchers now...
by eLife The equation symbolizing the mathematical model of osteoporosis overlaid on an image showing osteoporotic fractures (red) in the thoracic spine. Credit: Spine X-ray Friederike Thomasius; collage created by David Jörg A new model, described today in eLife, may help improve outcomes for patients with postmenopausal osteoporosis and reduce the risks of side effects by helping...
