A team of international researchers, including McGill Professor Stéphane Laporte, have discovered the working mechanism of potential drug targets for various diseases such as cancer, rheumatoid arthritis, and even COVID-19. The findings published in Molecular Celluncover the inner workings of cell receptors that are involved in cancer progression and inflammatory diseases. “The complement system is an integral part...
Tag: <span>Drug</span>
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Early-stage drug candidate diminishes deficits in Parkinson’s disease
by Jennifer Michalowski, University of Utah Health Sciences Figure 1. Activity of A-443654 in qHTS assays. (a) Molecular structure of A-443654. (b) Relative luciferase activity in SNCA-Luc (IC50=251 nM, triangles), CMV-luc (open circles) and viability (squares) of SNCA-luc cells measured after 24 hrs of treatment with A-443654 at the indicated doses. Credit: DOI: 10.1016/j.jbc.2021.101191 University of...
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Potential new drug for incurable vascular dementia
by University of Manchester Credit: Pixabay/CC0 Public Domain A drug already used to treat high blood pressure could be re-purposed as the first treatment to tackle a type of vascular dementia caused by damaged and ‘leaky’ small blood vessels in the brain, according to research part-funded by the British Heart Foundation and published today in the Journal of Clinical...
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Drug delivery capsule could replace injections for protein drugs
by Massachusetts Institute of Technology The new pill can inject large quantities of monoclonal antibodies and other drugs into the lining of the stomach after being swallowed. Credit: Giovanni Traverso In recent years, scientists have developed monoclonal antibodies—proteins that mimic the body’s own immune defenses—that can combat a variety of diseases, including some cancers and autoimmune...
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Virginia Tech scientists distill cow’s milk into nano-capsules for drug delivery
IMAGE: VIRGINIA TECH SCIENTISTS AT THE FRALIN BIOMEDICAL RESEARCH INSTITUTE AT VTC HAVE DEVELOPED A NOVEL WAY TO ISOLATE EXOSOMES FROM COW’S MILK. DONNIE MONTGOMERY (CENTER) OF LOCAL DAIRY PRODUCER HOMESTEAD CREAMERY PROVIDED THE SCIENTISTS WITH UNPASTEURIZED MILK SAMPLES FOR EXPERIMENTATION. THE RESEARCH TEAM (FROM LEFT) JANE JOURDAN, KEVIN PRIDHAM, ROB GOURDIE AND SPENCER MARSH...
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New class of drug gives hope to some ovarian cancer patients
by University of Washington School of Medicine Credit: CC0 Public Domain A study published today in Nature Communications shows that the drug rucaparib has been effective in treating certain types of ovarian cancers if used early in treatment, after a diagnosis, and before the cancer cells build up a resistance to chemotherapy. Rucaparib is in a relatively new class of...
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Drug derived from Kentucky-grown plant shows promise for ovarian cancer treatment
by Jenni Ho, University of Kentucky Researcher Kristen Hill, Ph.D., views ovarian cancer cells treated with Artemesia annua extracts. Credit: UK HealthCare Marketing A new study from University of Kentucky Markey Cancer researchers shows that Artemisia annua, a plant that has been traditionally used for its anti-malaria components, shows promise in treating ovarian cancer. The study,...
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CNIO researchers discover that a drug already in use in humans corrects obesity in mice
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) IMAGE: VISUALIZATION OF ADIPOCYTES FROM AN OBESE MOUSE (LEFT) AND FROM A LEAN MOUSE TREATED WITH DIGOXIN (RIGHT), SHOWING A BETTER RESPONSE TO NUTRIENT EXCESS AND BURNING OF FAT. CREDIT: CNIO It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of the...
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A drug that can stop tumors from growing
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center. In a paper published in the journal PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D’Alessandro, PhD, Morkos Henen,...
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Drug is promising against pancreatic and breast cancers
by Georgia State University Credit: CC0 Public Domain ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the Journal of Experimental...