Price competition’s society-altering test Illustration: Aïda Amer/Axios Two facts about GLP-1s tend to dominate conversations: Their effectiveness is almost too good to be true, and if everyone who could benefit from them received them — at least at current prices — the cost would be prohibitively expensive. Why it matters: With the development pipeline chock-full...
by Massachusetts Institute of Technology Credit: CC0 Public DomainAny drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s not known which of those transporters they use to exit the digestive tract. Identifying...
Marilynn Larkin There’s no question that glucagon-like peptide 1 (GLP-1) agonists represent a major advance in the treatment of obesity for patients with or without diabetes. In clinical trials, participants lost 15%-20% of their body weight, depending on the drug. But studies also have shown that once people stop taking these drugs — either by...
by Nancy Clanton, The Atlanta Journal-Constitution Credit: Pixabay/CC0 Public Domain America’s Poison Centers reported nearly 3,000 calls this year involving the weight loss drug semaglutide—a 15-fold increase since 2019, according to CNN. Some of the people calling described symptoms related to accidental overdose. Those who needed to be hospitalized usually recovered once they received fluids...
By Paul McClure Researchers have used a novel tech platform to screen and identify drugs that interrupt the spread of melanoma Researchers have developed an automated platform that they’ve used to screen thousands of drugs and identify those that can be used to interrupt the spread of melanoma, one of which they successfully trialed on mice....
Know what you’re in for before taking the risk. BbyY JOCELYN SOLIS-MOREIRA Semaglutides like Ozempic and Wegovy have weight loss benefits, but also some possibly harmful side effects. Jaap Arriens/NurPhoto via Getty ImagesSHARE You’ve probably heard a lot about Ozempic and Wegovy, the semaglutide wonder drugs for weight loss. Their newfound popularity with prescribers and online...
by University of Bath Credit: University of BathAn affordable microneedle skin patch that delivers a controlled dosage of medicine directly into the body, eliminating the need for injections or oral medication, has been developed by a team led by scientists at the University of Bath. It is hoped that the patches, which are described in the...
UNIVERSITY OF CALIFORNIA, IRVINE The use of glucagon-like peptide-1 receptor agonists in weight-loss drugs like Ozempic and Wegovy to treat childhood obesity and type 2 diabetes may have unintended and adverse consequences for children’s health, according to a team of clinicians, exercise scientists, pharmaceutical scholars, ethicists, and behavioral experts. Their commentary appears as a perspective...
by British Medical Journal New drugs are often used not only for one disease (first approved indication) but also for other diseases (supplemental indications). But a study published by The BMJ finds that less than half of approved first indications for new drugs in the U.S. and Europe between 2011 and 2020 add substantial therapeutic value over existing...
Reviewed by Megan Craig, M.Sc. Jun 15 2023 A medication called bempedoic acid reduced the risk of cardiac events as well as statins and may offer an alternative to the popular cholesterol-reducing medications, according to industry-supported research being presented Thursday at ENDO 2023, the Endocrine Society’s annual meeting, in Chicago, Ill. Statins are widely prescribed...
