Tyler Patchen News Reporter The FDA has warned the public that compounded versions of popular GLP-1 drugs Ozempic and Wegovy may not include the same ingredients as the prescription medications, and that has raised questions about their safety and effectiveness. The regulator said Tuesday it has received reports of adverse events related to compounded versions...
Tag: <span>Drugs</span>
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Engineers design sutures that can deliver drugs or sense inflammation
by Massachusetts Institute of Technology Credit: Pixabay/CC0 Public Domain Inspired by sutures developed thousands of years ago, MIT engineers have designed “smart” sutures that can not only hold tissue in place, but also detect inflammation and release drugs. The new sutures are derived from animal tissue, similar to the “catgut” sutures first used by the ancient Romans....
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Team discovers new drugs with potential for treating world’s leading causes of blindness in AMD, other diseases
by University of California, Irvine Molecular mechanisms of stress resilience-enhancing drug (SRED) therapy. Retinal degeneration involves a complex, multifactorial combination of genetic factors and environmental exposures that accumulate over a lifetime and eventually overwhelm intrinsic stress resilience mechanisms, which can be enhanced pharmacologically by SREDs to alleviate disease and preserve vision. Credit: UCI School of Medicine...
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How drugs get into the blood?
Computer simulations have helped researchers understand how pharmaceutically active substances cross cell membranes. These findings can now be used to discover new drug candidates more efficiently. There is a need for new drugs. For example, many antibiotics we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active...
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Biden proposes extending Medicare price negotiations to more drugs
March 7, 2023 07:21 AM EST FDA+Law Zachary Brennan Senior Editor The White House put out word this morning that as part of its campaign to keep the Medicare program for seniors solvent, its newly formed drug price negotiations should be extended to even more drugs and take effect more quickly. Building on the Inflation...
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A new class of drugs could prevent resistant COVID-19 variants, study finds
by Yale University Credit: Pixabay/CC0 Public Domain The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2...
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Getting drugs across the blood-brain barrier using nanoparticles
MEMORIAL SLOAN KETTERING CANCER CENTER • The blood-brain barrier prevents most drugs from reaching brain tumors.• A new method using nanoparticles transported drugs across this barrier in mice.• The nanoparticles target a protein on tumor blood vessel cells called P-selectin.• The nanoparticles improved the treatment in a model of aggressive pediatric brain cancer Brain tumors...
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Researchers discover how to predict the efficacy of one of the most widely used drugs against breast cancer
by The Spanish National Cancer Research Centre Clinical trial tumor samples: the phosphoprofiles were independent of the study site and/or treatment arm. A Clinical trial treatment and sampling schedule. After randomization, patients were scheduled for a fresh tumor biopsy. Sixty-two and sixty-one patients allocated to the Experimental and Standard arms, respectively, consented to and underwent...
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Discovery boosts the potential of new cancer-fighting drugs
by The Scripps Research Institute Cancer cell during cell division. Credit: National Institutes of Health Scientists at Scripps Research have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective. CELMoDs are designed to attack cancer in a novel way, by binding to a regulatory protein called cereblon, which...
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New Nonstatin Cholesterol Lowering Drugs: How to Use Them
Neil Skolnik, MD September 27, 2022 I’m Dr Neil Skolnik, and today we are going to talk about the 2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Solution Set Oversight Committee, Journal of the American College...