MDedge News Marcia Frellick August 14, 2024 Topical sildenafil (citrate) cream 3.6% used by healthy premenopausal women with a primary symptom of female sexual arousal disorder did not show statistically significant improvement over placebo in the coprimary or secondary endpoints over a 3-month period in new preliminary study data published in Obstetrics & Gynecology. Topical...
Tag: <span>Dysfunction</span>
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Dysfunction of mitochondria drives the exhaustion of T cells, study shows
by Julius-Maximilians-Universität Würzburg a Adoptive co-transfer of WT (tdTomato+GFP+) and HIF-1α-deficient (tdTomato+) P14 T cells into C57BL/6 mice before chronic infection with LCMV clone 13 (LCMVCL13). 21 days post infection (d.p.i.), donor P14 WT and HIF-1α-deficient T cells were FACS sorted, barcoded, and multiplexed in a 1:1 ratio and subjected to single-cell RNA sequencing. Uniform manifold...
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Unraveling the mechanism behind obesity-induced pancreatic β-cell dysfunction
by University of Tsukuba Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112914 Obesity not only increases the risk of metabolic syndrome-related diseases, such as diabetes, fatty liver, and atherosclerosis, but also remarkably impacts seemingly unrelated conditions, such as cancer, psychiatric disorders, and immune function. To understand this wide range of diseases and develop therapeutic approaches for the...
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New diagnostic criteria shine light on early dementia mimics
by University of Bristol UK academics and clinicians have collaborated to develop a diagnostic definition of the widely recognised but poorly understood condition, Functional Cognitive Disorder (FCD). Credit: University of Bristol Experts estimate up to one third of people attending specialist memory clinics could have a condition that is commonly mistaken for early dementia. In...
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Mucus shows promise as cheap and easy diagnostic tool for Alzheimer’s
By Nick Lavars August 12, 2020 Alzheimer’s researchers Professor Cheil Moon (left) and Gowoon Son (right) analyzing nasal discharge samples in the lab at Daegu Gyeongbuk Institute of Science and TechnologyDaegu Gyeongbuk Institute of Science and Technology VIEW 1 IMAGES With so much we are yet to understand about how Alzheimer’s develops, scientists are coming...
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An Age-Related Increase in CD47 Expression Impairs Vascular Function
This news or article is intended for readers with certain scientific or professional knowledge in the field. Researchers here provide evidence to indicate that increased expression of CD47 in aged blood vessels impairs a range of functions, from maintenance of these tissues to the generation of new blood vessels. The latter point is interesting given...
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BALDNESS MAY BE A RISK FACTOR FOR COVID-19
Two small studies published recently suggested most men hospitalized with Covid-19 are bald, generating headlines around the world. While this may sound strange, science does offer a plausible explanation. Male pattern baldness is associated with high levels of male sex hormones called androgens. And androgens seem to play an important role in the entry of...
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Squid studies illuminate neural dysfunction in ALS; suggest new route to therapy
CREDIT: DANIEL COJANU WOODS HOLE, Mass. — Amyotrophic lateral sclerosis (ALS) is one of the most devastating adult-onset neurodegenerative diseases. Patients, including the late actor/playwright Sam Shepard, become progressively weaker and eventually paralyzed as their motor neurons degenerate and die. To find a cure for ALS, which is fatal, scientists need a deeper understanding of...
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PSA screening affords men long-term benefits, study finds
The benefits of the prostate-specific antigen (PSA) test to screen men for prostate cancer may be greater than the harm, according to a study published in the New England Journal of Medicine. Genitourinary cancer specialists from Seattle Cancer Care Alliance, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, and Weill Cornell Medicine...
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Update on stem cells for COVID-19, Surgisphere scandal
The term Regenerative Medicine covers so much biomedical science these days including everything from just about any kind of cell therapy (not just stem cells) to CRISPR gene editing, and with the the COVID-19 pandemic, it seems this umbrella use of the term now includes potential treatment of viral illnesses. It can be hard to...
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