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How Dysregulated Cell Signaling Causes Disease

By Deliana InfanteReviewed by Danielle Ellis, B.Sc. What is cell signaling?How cell signaling goes wrongThe impact of dysregulated cell signalingTherapeutic targets and future directionsReferencesFurther reading Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, improper immune responses, or...

Sex-specific mechanisms for major depressive disorder identified in response to dysregulated stress hormones
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Sex-specific mechanisms for major depressive disorder identified in response to dysregulated stress hormones

by Melissa Rohman,  Northwestern University Chronic corticosterone treatment significantly decreases tissue dopamine content of the dorsomedial striatum (DMS) in female mice. A Experimental timeline for pellet implantation, tissue punches, and HPLC-ECD of dopamine. B Tissue dopamine content of the nucleus accumbens core (NAcc) of placebo- and CORT-treated male and female mice. C Tissue dopamine content of...