ELSEVIER IMAGE: FRESH VOIDED URINE SAMPLES WERE COLLECTED INTO TUBES CONTAINING PRESERVATIVE BUFFER. TOTAL DNA WAS EXTRACTED FROM THE URINE SEDIMENTS AND UNDERWENT BISULFITE CONVERSION. SUBSEQUENTLY, LINEAR TARGET ENRICHMENT (LTE) AND QUANTITATIVE METHYLATION-SPECIFIC PCR (QMSP) WERE CONDUCTED TO DETERMINE THE LEVEL OF PENK METHYLATION ASSOCIATED WITH BLADDER CANCER. A POSITIVE RESULT INDICATES A HIGHER PROBABILITY...
by Emily Moskal, Stanford University Imaging approach for the detection of activated peripheral CNS-infiltrating myeloid cells. Peripheral myeloid cells (monocytes, macrophages, neutrophils, and dendritic cells) are recruited to the central nervous system (CNS) during multiple sclerosis (MS). Peripheral myeloid cells, in addition to brain resident microglia, are associated with CNS MS lesions and are fundamental to...
The AD-Detect™ Test for Alzheimer’s disease, a blood-based biomarker test, is now available for purchase by consumers in the United States. Image credit: Jasmin Merdan/Getty Images. Quest Diagnostics has introduced the AD-Detect™ Test for Alzheimer’s disease, a blood-based biomarker test available for purchase by consumers. The new test allows individuals to gauge their risk of...
by UT Southwestern Medical Center Median protein concentrations found in vaginal secretions of four patient cohorts. Overall, the four groups were significantly different from one another (P = 0.016), with the greatest difference seen between the pre-P and post-NP groups (P = 0.007). The highest overall protein expression was found in the pre-P group with the lowest found in the post-P group....
by Laurie Fickman, University of Houston Antibody pair selection for construction of ALCAM LFA. (A) 57 antibody pairs (eight types of antibodies were tested in all combinations and with each serving as detection Ab-the antibody conjugated onto the nanophosphors and as capture Ab-the antibody immobilized onto the LFA strip) were tested for ALCAM LFA performance,...
by National University of Singapore A working model for integrin αvβ1 in the tumor microenvironment. Credit: Journal of Extracellular Vesicles One woman is diagnosed with breast cancer every 14 seconds somewhere around the globe—based on data showing that an approximate 2.3 million women worldwide were newly diagnosed with breast cancer in 2020. In Singapore, it is...
by Max Planck Society By using mass spectrometry-based proteomics, researchers were able to measure the intensity of important proteins (biomarkers, peaks in the graph) and therefore diagnose alcohol-related liver disease at an early stage. Credit: Lili Niu / Novo Nordisk Foundation, Center for Protein Research Two or three drinks every day could put your liver...
UNIVERSITY OF BARCELONA IMAGE: Schematic of the experimental design for investigating the emergence of functional alterations in dopaminergic neurons obtained from PD patient-specific iPSC. After their generation in the plate, monitorisation of calcium intracellular levels has been used to follow the organizational changes and dynamical traits of the neuronal networks during maturation. Functional analysis of...
THE NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY IMAGE: UNHEALTHY LIFESTYLES, VARIOUS DISEASES, STRESS, AND AGING CAN ALL CONTRIBUTE TO AN IMBALANCE BETWEEN THE PRODUCTION OF ROS AND THE BODY’S ABILITY TO REDUCE AND ELIMINATE THEM. THE RESULTING EXCESSIVE LEVELS OF ROS CAUSE “OXIDATIVE STRESS. CREDIT: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE...
By Ana Sandoiu Fact checked by Isabel Godfrey New research presents a complex electronic device as a possible new, efficient, simple, and cost-effective way of detecting bladder cancer in its early stages and monitoring people living with bladder cancer. The American Cancer Society (ACS) estimate that bladder cancer will affect 80,470 people in the United States this year. About 17,670 deaths are...
