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Continued Caution Needed Combining Nitrates With ED Drugs

Megan Brooks New research supports continued caution in prescribing a phosphodiesterase-5 inhibitor (PDE5i) to treat erectile dysfunction (ED) in men with heart disease using nitrate medications. In a large Swedish population study of men with stable coronary artery disease (CAD), the combined use of a PDE5i and nitrates was associated with a higher risk for...

The significant impact of ED drugs on men’s cardiac health
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The significant impact of ED drugs on men’s cardiac health

by Huntington Medical Research Institutes  Key Kaplan-Meier plots from matched plus multivariable adjusted analyses. Note that the first 2 adjusted survival curves for MACE (A) and overall mortality (B) show that exposed group had improved survival and that the lines continued to separate over time in favor of exposure extending to 150 months. C and D show a...