The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science. Human bodies contain over 200 different types of specialized cells. All of...
by Cristy Lytal, University of Southern California Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida are whispering the secrets of a simpler way to generate the sensory cells of the inner ear. Their approach uses direct reprogramming to produce sensory cells known as “hair cells,” due to their hair-like protrusions...
A new study shows that when specific human brain cells are transplanted into animal models of multiple sclerosis and other white matter diseases, the cells repair damage and restore function. The study provides one of the final pieces of scientific evidence necessary to advance this treatment strategy to clinical trials. “These findings demonstrate that through...
After 20 years of hope, promise and controversy, human embryonic stem cells are reshaping biological concepts and starting to move into the clinic. Neural rosettes, derived from human embryonic stem cells, assemble into spheres in culture. Dieter Egli was just about to start graduate school in 1998 when researchers first worked out how to derive...
Pregnant woman. Stem cells found in amniotic fluid can be transformed into a more versatile state similar to embryonic stem cells, according to a new study. Stem cells found in amniotic fluid can be transformed into a more versatile state similar to embryonic stem cells, according to a study published July 3 in the journal Molecular...
miR-34a-deficient embryonic stem cell culture is enriched with cells with expanded developmental potential as shown by their strong MuERV-L induction (red). These cells are distinct from the classic embryonic stem cells shown by the Oct4 staining (green). MuERV-L are the family of murine endogenous retroviruses activated in the very early embryo. Researchers from the University...
