by University of Texas Health Science Center at Houston Credit: Pixabay/CC0 Public Domain Targeting a specific enzyme in the muscle could help cancer patients preserve muscle mass and potentially prolong their survival, according to research from UTHealth Houston. A study led by Yi-Ping Li, Ph.D., professor in the Department of Integrative Biology and Pharmacology with...
by Mallory Locklear, Yale University Credit: Michael S. Helfenbein An enzyme found in the brain acts as a major regulator of body weight, Yale researchers have discovered. In a new study, they found that removing the enzyme from neurons in a part of the brain known as the hypothalamus led mice to gain weight and...
Researchers at the University of Wisconsin–Madison have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new insight into how a human cell preserves the integrity of its DNA through repeated cell division. DNA replication is essential for perpetuating life as we know it,...
by Bob Yirka, Medical Xpress Using human cancer cell lines to investigate the origins of APOBEC3-associated mutagenesis. a, The experimental design used to track mutation acquisition in vitro over specific timeframes. The schematic was generated using BioRender. b, Profiles of APOBEC-associated signatures (sig.) extracted from SBSs identified across mutational catalogs of 5 stock cell lines...
by American Physiological Society High-resolution model of six insulin molecules assembled in a hexamer. Credit: Isaac Yonemoto/Wikipedia Physiologists at the Medical College of Wisconsin have identified the enzyme thioredoxin reductase as playing a key role in protecting beta cells from oxidative stress and in the regulation of insulin secretion. Researchers also show in this study that...
Researchers at Karolinska Institutet recently published a study in NPJ Biofilms and Microbiomes, that describes the findings of an enzyme that breaks down lipids. In nature, microorganisms including bacteria display different shapes. Escherichia coli, a rod-shaped commensal bacterium of the human gut, can readily alter its shape upon exposure to stress. Upon many occasions, E. coli stalls cell division...
by University of Bonn Plasticity of neuronal communication elicited by 48-hour blockade of neuronal activity correlates with the number of RIM molecular clusters in the active zone. Column A is imaged with widefield illumination; column B is imaged with dStorm microscopy; column C shows molecular clusters. Credit: © Group Schoch McGovern Our bodies have the...
By Dr. Tomislav Meštrović, MD, Ph.D.Aug 23 2021 By applying a systems biology approach, a recent bioRxiv* preprint research paper by scientists from the Icahn School of Medicine at Mount Sinai in New York unveils interactions between the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and p38 mitogen-activated protein kinase (MAPK) pathway responsible for regulating the expression of crucial inflammatory...
by University of South Australia Credit: Unsplash/CC0 Public Domain University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide. This enzyme, NEDD4-2, is critical for kidney health, says UniSA Centre for Cancer Biology scientist Dr. Jantina Manning in a new paper published this month...
UNIVERSITY OF WÜRZBURG IMAGE: VIOLET LIGHT TRIGGERS A SIGNALLING CHAIN IN THE LIGHT SENSOR PROTEIN SWITCH-CYCLOP, BLUE OR GREEN LIGHT STOPS THE CHAIN. AT THE END, THE PRODUCTION OF THE SIGNALLING MOLECULE CGMP IS REGULATED BY THE ENZYME GUANYLYL CYCLASE (GC). CREDIT: (PICTURE: SHIQIANG GAO / UNIVERSITY OF WUERZBURG) The unicellular green alga Chlamydomonas reinhardtii...
