Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system’s inflammation response to infection. By using both specially cultured cells and small animal models, HDAC3 was found to be directly involved in the production of agents...
Tag: <span>Enzyme</span>
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Researchers discover molecule that may be linked to athletic performance
by University of Bergen Carnosine and its precursor beta-alanine increase muscle strength, and have recently become extremely popular as dietary supplements in competitive sports. Researchers at University of Bergen, Norway, have recently discovered an enzyme that forms beta-alanine from the common amino acid aspartic acid. “This contrasts conventional wisdom that most beta-alanine is generated by...
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Phosphoprotein biomarkers to guide cancer therapy are identified
by University of Alabama at Birmingham Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients. Now researchers led by James Bibb, Ph.D., professor of surgery at the University of Alabama at Birmingham, suggest using a broader lens of post-translational modification analysis to identify new...
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AsEH enzyme: A new pharmacological target against Alzheimer’s disease
Drugs with neuroprotector effects UNIVERSITY OF BARCELONA FROM LEFT TO RIGHT, SANTIAGO VÁZQUEZ, CARLES GALDEANO, MERCÈ PALLÀS AND CHRISTIAN GRIÑÁN-FERRÉ (FACULTY OF PHARMACY AND FOOD SCIENCES/UNIVERSITY OF BARCELONA)…. view more CREDIT: UNIVERSITY OF BARCELONA A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer’s disease. The results show the...
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Researchers track down metabolic enzyme that protects against inflammation
by La Jolla Institute for Immunology Scrape your knee, and you’ll see some red puffiness appear around the injury. This is inflammation, and it is driven by the immune system. Inflammation around a scrape is minor, but inflammation around joints—due to diseases like rheumatoid arthritis—can be incredibly painful. And inflammation in and around the blood...
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Fast-spreading mutation helps common flu subtype escape immune response
by Johns Hopkins University Bloomberg School of Public Health Strains of a common subtype of influenza virus, H3N2, have almost universally acquired a mutation that effectively blocks antibodies from binding to a key viral protein, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health. The results have implications for flu...
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A chemical tailor-made suit for Alzheimer’s drugs
Research team from Göttingen and Halle develops new inhibitors for enzymes PROTEIN CRYSTALS OF THE HUMAN ENZYME GLUTAMINYL CYCLASE AND ATOMIC STRUCTURE OF THE NEW INHIBITOR. view more CREDIT: LISA-MARIE FUNK With over 1.2 million people affected in Germany alone and over 50 million people worldwide, Alzheimer’s disease, also referred to simply as Alzheimer’s, is...
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RNA key in helping stem cells know what to become
Findings could lead to new therapies for cancer, heart abnormalities UNIVERSITY OF COLORADO AT BOULDER Look deep inside our cells, and you’ll find that each has an identical genome -a complete set of genes that provides the instructions for our cells’ form and function. But if each blueprint is identical, why does an eye cell...
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Compounds halt SARS-CoV-2 replication by targeting key viral enzyme
by University of South Florida Three configurations of active sites where inhibitor GC-376 binds with the COVID-19 virus’s main protease (drug target Mpro), as depicted by 3D computer modeling. Credit: Image generated by Yu Chen, University of South Florida Health, using X-ray crystallography As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue...
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The gut shields the liver from fructose-induced damage
by Perelman School of Medicine at the University of Pennsylvania After one consumes food or a beverage containing fructose, the gastrointestinal system, or gut, helps to shield the liver from damage by breaking down the sugar before it reaches the liver, according to a new multi-center study led by researchers in the Perelman School of...