by Fabio Bergamin, ETH Zurich Human AT retains cellular transcriptional changes after BaS-induced WL. Credit: Nature (2024). DOI: 10.1038/s41586-024-08165-7 Anyone who has ever tried to get rid of a few extra kilos knows the frustration: the weight drops initially, only to be back within a matter of weeks—the yo-yo effect has struck. Researchers at ETH Zurich have now...
Tag: <span>epigenetic</span>
Post
Epigenetic change to DNA associated with cancer risk in ‘multi-omics’ study
August 9, 2024 by Leigh MacMillan, Vanderbilt University DNA, which has a double-helix structure, can have many genetic mutations and variations. Credit: NIHA research team co-led by investigators at Vanderbilt University Medical Center and the University of Virginia has identified associations between DNA methylation and cancer risk. DNA methylation is an epigenetic change—the addition of...
Post
Researchers Uncover How Gene Traits Are Passed On
Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases. the University of Hong Kong Credit: iStock. A research team led by Professor Yuanliang ZHAI at the School of Biological Sciences, The University of Hong Kong (HKU) collaborating with Professor Ning GAO and Professor Qing LI from Peking University...
Post
Team discovers how to predict whether patients with leukemia will be sensitive to epigenetic drugs
by Josep Carreras Leukaemia Research Institute Credit: Cancer Research Communications (2024). DOI: 10.1158/2767-9764.CRC-23-0389Alterations in the chemical modifications that control gene expression, known as epigenetics, have proven to be one of the most characteristic properties of all human tumors. This realization has generated the development of intense pharmacological research to find drugs that act at this level...
Post
Researchers discover epigenetic status determines metastasis
by German Cancer Research Center Credit: Unsplash/CC0 Public DomainScientists from the German Cancer Research Center (DKFZ) and Heidelberg University have investigated in mice how spreading tumor cells behave at the site of metastasis. Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy. What...
Post
Cannabis Use Linked to Epigenetic Changes, Scientists Reveal
ByREBECCA DYER (Marshall Pitman/Canva Pro)Using cannabis may cause changes in the human body’s epigenome, a study of over 1,000 adults suggests. The epigenome functions like a set of switches, activating or deactivating genes to change how our bodies function. “We observed associations between cumulative marijuana use and multiple epigenetic markers across time,” Lifang Hou, a...
Post
Boys who smoke in their early teens found to risk passing on harmful epigenetic traits to future children
By University of Southampton smoking teensCredit: Pixabay/CC0 Public DomainA new study suggests boys who smoke in their early teens risk damaging the genes of their future children, increasing their chances of developing asthma, obesity and low lung function. Research published in Clinical Epigenetics is the first human study to reveal the biological mechanism behind the...
Post
Looking at the role epigenetics plays in the ways cancer behaves
by Bob Yirka, Medical Xpress Genetic control of expression with eQTL. a, The number of genes with significant models for each data type. b, Distribution of regression coefficients (effect sizes) for each data type. c,d, Volcano plots highlighting selected genes significant for SCNA (c) and Mut eQTLs (d) (linear regression two-sided t-tests; Padj, FDR-adjusted P values). e,...
Post
Epigenetic biomarkers predict CVD risk
by Will Doss, Northwestern University Credit: Pixabay/CC0 Public Domain Epigenetic biomarkers may reflect past cardiovascular health exposures and predict cardiovascular disease in the future, according to a Northwestern Medicine study published in the journal Circulation. These biomarkers measured around midlife reveal valuable health information from a patient’s past, according to Yinan Zheng, Ph.D., assistant professor of Preventive...
Post
Study sheds new light on how epigenetic events might spur disease
by C. David Allis, Rockefeller University Scientists are increasingly tracing a variety of diseases back to the so-called epigenome, a type of indexing system imposed on DNA that dictates how genes should be read by the cells. Now, a new study finds that changes in two epigenetics mechanisms—DNA and histone methylation—may interact to spur disease. The...
- 1
- 2