by Johannes Angerer, Medical University of Vienna In DNMT1 deficient keratinocytes, DNA hypomethylation induces transposon derepression, mitotic defects and formation of micronuclei. DNA released into the cytosol by micronulear rupture activates signaling through cGAS and STING, further activating inflammation by ISG induction. Credit: DOI: 10.15252/embj.2021108234 The innate human immune system is capable of recognizing and fighting...
