UNIVERSITY OF CALIFORNIA – SANTA CRUZ IMAGE: IN A STUDY OF EPIGENETIC INHERITANCE, RESEARCHERS CREATED EMBRYOS OF THE WORM C. ELEGANS THAT INHERITED EGG CHROMOSOMES PROPERLY PACKAGED WITH THE EPIGENETIC MARK H3K27ME3 AND SPERM CHROMOSOMES LACKING THE MARK. THE ONE-CELL EMBRYO ON THE LEFT INHERITED THE PINK CHROMOSOMES FROM THE EGG AND THE GREEN CHROMOSOMES...
by Hillary Sanctuary, Ecole Polytechnique Federale de Lausanne HDACi treatment enhances contextual fear memory formation and hippocampal, but not striatal LTP, despite reducing HDAC activity in both brain regions. (A) Schematic of the experimental outline. (B) HDACi combined with CFC increases the percent of time spent freezing (>1 s) during 3-min reexposure to the conditioning chamber...
