by Manel Esteller and Alberto Bueno-Costa, Josep Carreras Leukaemia Research Institute Researchers of the Josep Carreras Leukaemia Research Institute discover that a leukaemic cell is capable of transforming into a non-cancerous cell through epigenetic changes. All the tissues of our body have the same DNA, but they perform very different functions and have very different aspects. For example, a lymphocyte and a neuron share...
Tag: <span>epigenetic</span>
Post
Researchers find epigenetic loss that changes how cells obtain energy from cancer
Cheap energy for the tumor cell UNIVERSITY OF BARCELONA It has been known for decades that cancer cells have an altered metabolism and it is seen in several biochemical pathways and in particular, in the way they get energy for their survival. If healthy cells use the mitochondrial respiratory chain, tumors use aerobic glycolysis, a process that...
Post
New epigenetic drug strategy to treat cancer
TEMPLE UNIVERSITY HEALTH SYSTEM (Philadelphia, PA) – Researchers have discovered that inhibiting CDK9, a DNA transcription regulator reactivates genes that have been epigenetically silenced by cancer. Reactivation leads to restored tumor suppressor gene expression and enhanced anti-cancer immunity. It is the first time this particular kinase has been linked to gene silencing in mammals. Jean-Pierre...
- 1
- 2