MONELL CHEMICAL SENSES CENTER PHILADELPHIA (August 24, 2023) – A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study published in iScience, by Hong Wang, PhD, an Associate Member at the Monell Chemical Sense Center,...
Tag: <span>epigenetics</span>
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Opioids and the brain: New insights through epigenetics
by Greta Friar, Whitehead Institute for Biomedical Research Credit: Pixabay/CC0 Public Domain Drug overdose, mostly from opioid use, is the leading cause of accidental death in the United States. Prior studies of twins have revealed that genetics play a key role in opioid use disorder. Researchers know that a mixture of genetic and environmental risk...
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Epigenetics, the misunderstood science that could shed new light on ageing
A little over a decade ago, a clutch of scientific studies was published that seemed to show that survivors of atrocities or disasters such as the Holocaust and the Dutch famine of 1944-45 had passed on the biological scars of those traumatic experiences to their children. The studies caused a sensation, earning their own BBC Horizon documentary and the cover...
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Novel pharmacological strategies to treat alcoholism. Focus on epigenetics
BENTHAM SCIENCE PUBLISHERS IMAGE: ALCOHOL INFLUENCES EPIGENETIC MODIFICATIONS AFFECTING DIFFERENT BIOMOLECULES’ FUNCTIONING–DRUG DESIGN SEARCHES FOR COMPOUNDS THAT MODULATE EPIGENETIC MECHANISMS. REPRESENTATIONS OF BIOMOLECULES ARE FROM PROTEIN DATA BANK; CODE FOR HISTONES IS 3AFA, DNA representation is from doi.org/105281/zenodo.4012404. CREDIT: DR. F. DAVID RODRIGUEZ Abusive alcohol drinking considerably impacts human health. Alcoholism, better defined as Alcohol...
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Driving immunometabolism to control lung infection
TRINITY COLLEGE DUBLIN When drugs to kill microbes are ineffective, host-directed therapy uses the body’s own immune system to deal with the infection. This approach is being tested in patients with COVID-19, and now a team of researchers at Trinity College Dublin has published a study showing how it might also work in the fight...
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Smart structures: Structural cells of the body control immune function
by Austrian Academy of Sciences Schematic outline of the study, which used genomic assays (RNA-seq, ATAC-seq, ChIPmentation, flow cytometry) to investigate epigenetic and transcription regulation in structural cells (endothelium, epithelium and fibroblast) from twelve mouse organs. Credit: Thomas Krausgruber / CeMM In a Nature paper, CeMM researchers report on the epigenetic and transcriptional regulation in...
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Premature epigenomic aging acts like a ‘sleeper cell’ that is awakened by Western-style diet
by Baylor College of Medicine The epigenome is sometimes referred to as the “software” or “operating system” of the genome. It comprises small chemical modifications to DNA and the proteins that make up our chromosomes, and controls the activity of all the genes within the genome. During early life, as our organs develop, the epigenome...
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First Epigenetic Study in 3D Human Cancer Cells
Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab. One explanation is that many of the tumor models used in early research phases are established cell lines that have been growing for...
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Cancer research breakthrough as DNA behavior is uncovered in 3D models
CREDIT: DR MANEL ESTELLER Scientists have used 3D models to break down the DNA behavior of cancer cells, in a breakthrough new study which could revolutionize treatment for the disease. In what is a first for science, a research team led by Dr Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute (IJC), demonstrated...
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Study sheds new light on how epigenetic events might spur disease
by C. David Allis, Rockefeller University Scientists are increasingly tracing a variety of diseases back to the so-called epigenome, a type of indexing system imposed on DNA that dictates how genes should be read by the cells. Now, a new study finds that changes in two epigenetics mechanisms—DNA and histone methylation—may interact to spur disease. The...
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