July 25, 2024 by Ecole Polytechnique Federale de Lausanne Neurons have variable levels of chromatin compaction, shown as different shades of red. The less compact a neuron, the more likely it is to be recruited into the memory trace (green). Credit: Giulia Santoni (EPFL)When we form a new memory, the brain undergoes physical and functional...
NEWS RELEASE 23-JUL-2024 Heart condition because of stroke? A new LMU study discovers why this can happen – and how we can counter it in future Peer-Reviewed PublicationLUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs – such as the heart. “However,...
MONELL CHEMICAL SENSES CENTER PHILADELPHIA (August 24, 2023) – A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study published in iScience, by Hong Wang, PhD, an Associate Member at the Monell Chemical Sense Center,...
by Greta Friar, Whitehead Institute for Biomedical Research Credit: Pixabay/CC0 Public Domain Drug overdose, mostly from opioid use, is the leading cause of accidental death in the United States. Prior studies of twins have revealed that genetics play a key role in opioid use disorder. Researchers know that a mixture of genetic and environmental risk...
A little over a decade ago, a clutch of scientific studies was published that seemed to show that survivors of atrocities or disasters such as the Holocaust and the Dutch famine of 1944-45 had passed on the biological scars of those traumatic experiences to their children. The studies caused a sensation, earning their own BBC Horizon documentary and the cover...
BENTHAM SCIENCE PUBLISHERS IMAGE: ALCOHOL INFLUENCES EPIGENETIC MODIFICATIONS AFFECTING DIFFERENT BIOMOLECULES’ FUNCTIONING–DRUG DESIGN SEARCHES FOR COMPOUNDS THAT MODULATE EPIGENETIC MECHANISMS. REPRESENTATIONS OF BIOMOLECULES ARE FROM PROTEIN DATA BANK; CODE FOR HISTONES IS 3AFA, DNA representation is from doi.org/105281/zenodo.4012404. CREDIT: DR. F. DAVID RODRIGUEZ Abusive alcohol drinking considerably impacts human health. Alcoholism, better defined as Alcohol...
TRINITY COLLEGE DUBLIN When drugs to kill microbes are ineffective, host-directed therapy uses the body’s own immune system to deal with the infection. This approach is being tested in patients with COVID-19, and now a team of researchers at Trinity College Dublin has published a study showing how it might also work in the fight...
by Austrian Academy of Sciences Schematic outline of the study, which used genomic assays (RNA-seq, ATAC-seq, ChIPmentation, flow cytometry) to investigate epigenetic and transcription regulation in structural cells (endothelium, epithelium and fibroblast) from twelve mouse organs. Credit: Thomas Krausgruber / CeMM In a Nature paper, CeMM researchers report on the epigenetic and transcriptional regulation in...
by Baylor College of Medicine The epigenome is sometimes referred to as the “software” or “operating system” of the genome. It comprises small chemical modifications to DNA and the proteins that make up our chromosomes, and controls the activity of all the genes within the genome. During early life, as our organs develop, the epigenome...
Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab. One explanation is that many of the tumor models used in early research phases are established cell lines that have been growing for...
