DARTMOUTH HEALTH LEBANON, NH— Advanced estrogen receptor-positive (ER+) breast cancer can be especially difficult to treat. A new study by researchers at Dartmouth Cancer Center led by Todd W. Miller, PhD, shows promise in using a combination of estrogen and a PARP inhibitor (a drug that suppresses DNA damage repair), to treat this type of cancer. Estrogen...
Tag: <span>estrogen</span>
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Estrogen may offer protection against delirium
by Cedars-Sinai Medical Center Oophorectomy (OVX) and urinary tract infection (UTI)-mediated changes in cleaved caspase-3 (CC3). (A) A schematic of design of a preliminary experiment examining the effects of OVX, UTI, and OVX + UTI on levels of cortical and hippocampal CC3. (B) Representative regions of interest (ROIs) in the frontal cortex and hippocampus. (C) Representative staining...
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Nicotine dose in a single cigarette blocks estrogen production in women’s brains
by European College of Neuropsychopharmacology Aromatase (estrogen synthetase) detected in the thalamus (red spot). Credit: Jana Immenschuh A dose of nicotine, equivalent to that found in a single cigarette blocks estrogen production in women’s brains. This may explain several behavioral differences in women who smoke, including why they are more resistant than men to quitting...
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Estrogen enhances cardiac function, promotes energy metabolism
by Texas A&M University Shaodong Guo, Ph.D., in his laboratory. Credit: Texas A&M AgriLife photo Estrogen may protect diabetes patients from cardiomyopathy, according to research led by a Texas A&M AgriLife scientist and published in the June issue of Circulation: Heart Failure. The study showed that severe insulin resistance in the heart causes cardiomyopathy and death in male mice....
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First treatment identified for fainting
Sophia Antipolis, France – 1 Sept 2020: Fainting affects one in two people during their lifetime. Those with recurrent episodes are often afraid to socialise or go to work. Today researchers report the first effective therapy. The late breaking research is presented at ESC Congress 2020.1 Fainting is caused by a fall in blood pressure...
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Imaging an estrogen related enzyme may help to predict obesity, self-control issues
by Stony Brook University Findings from a positron emission tomography (PET) brain imaging study of the amygdala reveals that low levels of the enzyme aromatase, which catalyzes estrogen biosynthesis, are associated with a higher body mass index (BMI) and lower self-control, as measured by a standard personality test. Published in PNAS, the study is led...
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Estrogen receptors might hold key in obesity prevention
by University of Missouri-Columbia Despite countless fad diets, both obesity and metabolic diseases continue to plague communities across the U.S. Now, researchers from the University of Missouri believe that the clue to treatment might be related to estrogen—for both men and women. In two separate studies, Vicki Vieira Potter and Jaume Padilla, researchers in the Department of Nutrition and Exercise Physiology,...
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Ultra-sturdy bones, with a surprising origin, suggest new osteoporosis approach
After blocking estrogen signals in brain, experts say they’ve ‘never seen bone this strong’ UNIVERSITY OF CALIFORNIA – SAN FRANCISCO IMAGE: BONES LIKE THE FEMUR (THIGH BONE) NORMALLY BECOME WEAK AND POROUS IN AGING MICE (71 WEEKS, LEFT), BUT AN EXPERIMENTAL CHANGE IN BRAIN SIGNALING LED TO MUCH DENSER AND STRONGER. CREDIT: CANDICE HERBER / UCSF...