WEST VIRGINIA UNIVERSITY Cells can’t text each other the way we can, but they can still communicate. One way they send each other messages is through exosomes–tiny, spherical “packages” of information they emit. David Klinke, a researcher with the West Virginia University School of Medicine and Cancer Institute, is deciphering the contents of exosomes that...
Tag: <span>exosome</span>
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High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
Abstract Targeting exosome biogenesis and release may have potential clinical implications for cancer therapy. Herein, we have optimized a quantitative high throughput screen (qHTS) assay to identify compounds that modulate exosome biogenesis and/or release by aggressive prostate cancer (PCa) CD63-GFP-expressing C4-2B cells. A total of 4,580 compounds were screened from the LOPAC library (a collection...