by University of Texas M. D. Anderson Cancer Center CNP generates large quantities of EVs loaded with COL1A1 mRNA. a, Schematic representation of CNP-generated EVs for targeted nucleic acid delivery. b, EV number per cell produced by untreated nHDFs in PBS buffer as control, BEP or CNP with PBS buffer only in 24 h (n = 3 for each group; *P = 0.048...
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: USUALLY, BLOOD VESSELS ARE STABILIZED, AND THEIR BARRIER FUNCTION IS MAINTAINED BY THE TIGHT ADHESION BETWEEN VASCULAR ENDOTHELIAL CELLS (①). WHEN CANCER CELLS METASTASIZE TO DISTANT ORGANS VIA BLOOD VESSELS, THE MORPHOLOGY OF VASCULAR ENDOTHELIAL CELLS CHANGES IN RESPONSE TO THE GROWTH FACTORS OR CYTOKINES SECRETED BY THE CANCER...
by The Endocrine Society Credit: Pixabay/CC0 Public Domain In a new Scientific Statement released today, the Endocrine Society describes the importance of extracellular vesicles as a new research target for understanding the causes of certain endocrine disorders such as cancer and diabetes and discovering new treatments for these disorders. During the last decade, endocrine researchers...
Much of cell signaling is carried via extracellular vesicles, membrane-wrapped packages of molecules. Researchers are finding that delivery of extracellular vesicles harvested from stem cells may be a good replacement for first-generation stem cell therapies, in which the transplanted cells produce benefits via signaling before dying. Extracellular vesicles are an easier, cheaper approach from a...
by Marissa Shapiro, Miquéla Thornton, Vanderbilt University Credit: Public Domain An international collaboration led by Vanderbilt researchers has found that a novel form of brain cell communication may influence brain function. The discovery was uncovered by Natalí L. Chanaday, postdoctoral scholar, A. Alejandro Vilcaes, assistant professor at the Universidad Nacional de Córdoba in Argentina and Ege...
by Harvard John A. Paulson School of Engineering and Applied Sciences Endothelial-derived EVs (green) around the nuclei (blue) of a cardiomyocyte (magenta). Extracellular vesicles (EVs)—nanometer sized messengers that travel between cells to deliver cues and cargo—are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injury....
