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An antibody-based drug triggers rare inflammatory eye problems in macular degeneration patients

by Delthia Ricks , Medical Xpress Neutralizing and non-neutralizing ADAs in complex with brolucizumab. A structural model of a complex comprised of one neutralizing anti-brolucizumab antibody in blue, and two non-neutralizing antibodies in light yellow. Brolucizumab is shown in gray, with the VEGF-A-binding CDRs highlighted in magenta. ADA, anti-drug antibody; CDR, complementarity-determining region; VEGF-A, vascular...

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How to relieve dry, irritated eyes

by Len Canter, Healthday Reporter  (HealthDay)—Do all the ads for dry eye relief have you thinking you could have this condition? If you’ve ever felt like you had a grain of sand in your eye when nowhere close to the beach, you could be experiencing dry eye. Exactly what is dry eye? Simply put, it’s...

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Blinking eye-on-a-chip used for disease modeling and drug testing

by Lauren Salig, University of Pennsylvania People who spend eight or more hours a day staring at a computer screen may notice their eyes becoming tired or dry, and, if those conditions are severe enough, they may eventually develop dry eye disease (DED). DED is acommon disease with shockingly few FDA-approved drug options, partially because of the difficulties of modeling the complex pathophysiology in human eyes. Enter the blinking eye-on-a-chip: an...