Advice by Trisha Pasricha, MD, MPH May 22, 2023 at 6:00 a.m. EDT Q: What is fatty liver disease? How do I know if I have it, and what can I do about it? A: Fatty liver disease is a condition in which normal tissue in the liver is replaced by fat. About one in five Americans has...
Tag: <span>fatty liver disease</span>
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New drug treats fatty liver disease in animal models, brings hope for first human treatment
by University of Michigan Credit: Pixabay/CC0 Public Domain A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates—bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests. Researchers at Michigan Medicine developed DT-109, a glycine-based tripeptide, to treat the...
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NUS researchers develop new imaging approach to diagnose advanced form of non-alcoholic fatty liver disease
NATIONAL UNIVERSITY OF SINGAPORE, YONG LOO LIN SCHOOL OF MEDICINE Non-alcoholic fatty liver disease is the most common chronic liver disease in the world. In its advanced form, Non-alcoholic steatohepatitis (NASH), is curable when diagnosed and treated in its early stages. However, when left untreated, it could progress to the irreversible stage of liver cirrhosis...
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Alternate-day fasting could be a good option for patients with fatty liver disease
by University of Illinois at Chicago Graphical abstract. Credit: Cell Metabolism (2022). DOI: 10.1016/j.cmet.2022.12.001 Nutrition researchers at the University of Illinois Chicago studied 80 people with nonalcoholic fatty liver disease and found that those who followed an alternate-day fasting diet and exercised were able to improve their health. Publishing their findings in Cell Metabolism, the researchers report that over...
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The efficiency of lifestyle intervention, orlistat, and experimental diet therapy in patients with obesity and metabolic-associated fatty liver disease
By Dr. Chinta Sidharthan Feb 14 2023 Reviewed by Danielle Ellis, B.Sc. In a recent study published in The American Journal of Clinical Nutrition, researchers compared the effects of an experimental low-carbohydrate and high-protein diet and orlistat with that of a control diet to examine their impact on Asian metabolic-associated fatty liver disease (MAFLD) patients with obesity. Study: Treatment of Obesity...
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Possible genetic basis and mouse model found for severe nonalcoholic fatty liver disease
by Liz Ahlberg Touchstone, University of Illinois at Urbana-Champaign The SRSF1 gene acts as a guardian against DNA damage in the liver, University of Illinois Urbana Champaign researchers found. When it is missing or inactivated, severe nonalcoholic fatty liver disease symptoms develop. Credit: Michael Vincent A mutant or damaged gene may be a cause of...
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Research shows fatty liver disease endangers brain health
by King’s College London Credit: Pixabay/CC0 Public Domain In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to King’s College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to...
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Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease
COMPUSCRIPT LTD Metabolic-associated fatty liver disease (MAFLD), which is previously known as non-alcoholic fatty liver disease (NAFLD), represents a major health concern worldwide with limited therapy. The authors of this article provide evidence that ferroptosis, a novel form of regulated cell death characterized by iron-driven lipid peroxidation, was comprehensively activated in liver tissues from MAFLD...
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Review sheds light on protein drug target for treating non-alcoholic fatty liver disease
by Cactus Communications A new CMJ article explores the possibility of using the transport protein Retinol-binding protein-4 as a therapeutic target to treat NAFLD. Credit: Albaraa Mehdar It is a known fact that consuming a large amount of alcohol, even for a few days, triggers fat accumulation in the liver and ultimately leads to alcohol-related...
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B vitamins can potentially be used to treat advanced non-alcoholic fatty liver disease
by Federico Graciano, Duke-NUS Medical School Western-style diets, which are typically high in fructose intake, can lead to elevated serum and hepatic homocysteine levels in blood (a medical condition known as hyperhomocysteinemia), which the research team found to be directly proportional to the severity of non-alcoholic steatohepatitis (NASH) in people with non-alcoholic fatty liver disease...