Neil Skolnik, MD I’m Dr Neil Skolnik. Today, we are going to talk about two guidelines: the American Association for the Study of Liver Diseases (AASLD) clinical assessment and management of nonalcoholic fatty liver disease (NAFLD) and the American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver...
Tag: <span>Fatty liver</span>
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Gut microbiota to be harnessed as a tool to diagnose diseases – promising results for fatty liver diagnosis
UNIVERSITY OF JYVÄSKYLÄ – JYVÄSKYLÄN YLIOPISTO A recent study at the University of Jyväskylä compared the gut microbiota and gut-derived metabolites between healthy controls and individuals with fatty liver. The results revealed that certain microbial metabolites are associated with liver fat content. The fact that the gut microbiota associates with many diseases, has raised the...
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Why severe fatty liver leads to liver damage
by Kanazawa University Schematic diagram of induction mechanism of acute and chronic liver damage in severe fatty liver. Credit: Kanazawa University In hepatic steatosis, hepatocytes “die,” resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis...
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Hormone protects against development of fatty liver
by Medical University of Vienna Graphical abstract. Credit: Cell Metabolism (2022). DOI: 10.1016/j.cmet.2022.09.020 A group at MedUni Vienna has identified a regulatory loop controlled by leptin, by which this adipocyte-derived hormone regulates hepatic lipid metabolism via the autonomic nervous system. The study, published in Cell Metabolism, provides evidence that this adipose tissue-brain-liver axis, previously identified in animal models,...
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Researchers reveal a new approach for clearer fatty liver observation
by Osaka Metropolitan University Cold enzymatic treatment and usage of an antibody against CD49a, a reliable HSC surface marker, minimized the generation of heat stress-associated artefacts and allowed the isolation of HSCs with high yield and high purity. Credit: Naoko Ohtani, Osaka Metropolitan University Obesity can give rise to a variety of health concerns. Nonalcoholic...
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New blood biomarker identified for status of fatty liver disease
by Johannes Angerer, Medical University of Vienna Graphical abstract. Credit: Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.06.004 A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against fibrosis and liver cirrhosis. At...
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Growth hormone improves liver health in people with nonalcoholic fatty liver disease
by The Endocrine Society Credit: Pixabay/CC0 Public Domain Growth hormone improves liver health in patients with nonalcoholic fatty liver disease (NAFLD) by reducing liver fat and inflammation, according to a new study presented Tuesday, June 14 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga. “Two risk factors for NAFLD, obesity and diabetes,...
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Nonalcoholic fatty liver disease subtypes exhibit distinctive cardiovascular risk profiles
by CIC bioGUNE Credit: Pixabay/CC0 Public Domain Nonalcoholic fatty liver disease (NAFLD), a disease affecting approximately one-quarter of the world’s adult population, reflects dysfunctional hepatic lipid metabolism. A better understanding of NAFLD heterogeneity and its biology will facilitate the development of personalized treatments. An international team of researchers, led by José M Mato at CIC...
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Eating less suppresses liver cancer due to fatty liver
SHINSHU UNIVERSITY IMAGE: 30% DIETARY RESTRICTION SUPPRESSES LIVER TUMORS FROM FATTY LIVER. Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Most often the cause...
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The gut shields the liver from fructose-induced damage
by Perelman School of Medicine at the University of Pennsylvania After one consumes food or a beverage containing fructose, the gastrointestinal system, or gut, helps to shield the liver from damage by breaking down the sugar before it reaches the liver, according to a new multi-center study led by researchers in the Perelman School of...
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