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New understanding of how faulty metabolism triggers adrenal cancer
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New understanding of how faulty metabolism triggers adrenal cancer

by Jeff Hansen, University of Alabama at Birmingham Credit: Priyanka Gupta et al, Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111218 Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands. This discovery explains how impaired metabolism due to mutations in a key enzyme called succinate dehydrogenase B disables a...