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Researchers identify specific genes and cell pathways as key players in rare female lung disease
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Researchers identify specific genes and cell pathways as key players in rare female lung disease

by Alex Gardner,  Perelman School of Medicine at the University of Pennsylvania Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signaling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in female breeder mice. These mice without TSC2 also exhibited a dysfunctional WNT cellular signaling...