COMPUSCRIPT LTD Metabolic-associated fatty liver disease (MAFLD), which is previously known as non-alcoholic fatty liver disease (NAFLD), represents a major health concern worldwide with limited therapy. The authors of this article provide evidence that ferroptosis, a novel form of regulated cell death characterized by iron-driven lipid peroxidation, was comprehensively activated in liver tissues from MAFLD...
Tag: <span>ferroptosis</span>
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Ferroptosis in Aging
Ferroptosis is a mode of programmed cell death that manages to be both fairly well explored in the broader research community and far less visible than other programmed cell death processes. It was first named and described a decade ago, though of course researchers have long explored aspects of its biochemistry. There is some thought...
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Researchers discover biochemical pathway that protects cells from ferroptosis
by H. Lee Moffitt Cancer Center & Research Institute Credit: Pixabay/CC0 Public Domain The hallmarks of cancer include rapid cell reproduction and metabolic activity. But these processes also lead to increased cellular stress and oxidation, and the risk of cell death. To circumvent these negative consequences of supercharged growth, cancer cells stimulate pathways to reduce oxidative stress and...
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Study finds fatty acid that kills cancer cells
by Washington State University Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published in Developmental Cell on July 10, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells. Ferroptosis is an iron-dependent type of cell death that...
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A new strategy to trigger ferroptosis in target cancer cells using drug-metal coordination complexes
by University of Science and Technology of China Rapidly increasing cancer incidence and mortality worldwide have raised great challenges for the currently available anticancer options, which warrants the development of new therapeutic modalities based on novel antitumor mechanisms. Ferroptosis, a recently discovered form of non-apoptotic cell death, is one such candidate and has already demonstrated...
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A powerful cell-protection system prevents cell death by ferroptosis
The discovery of a mechanism that guards against a type of cell death celled ferroptosis reveals a system that regenerates a ubiquitous protective component of biological membranes, and might offer a target for anticancer drugs. Brent R. Stockwell On 3 December 1956, the biochemist Frederick Crane detected, for the first time ever, a yellow substance...