by University of Southampton Schematic of Pan-Cancer Fibroblast Atlas (PCFA) including anatomical sites, sample/fibroblast numbers and original publications. Credit: Molecular Cancer (2025). DOI: 10.1186/s12943-024-02191-9 Southampton scientists working to improve survival for cancer patients have identified a key characteristic of the disease that could make treatment more effective. The aim of the University of Southampton study is for patients...
Tag: <span>fibroblast</span>
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Reprogramming cells for heart repair: New method transforms ordinary fibroblasts into mature cardiomyocytes
by Korea University College of Medicine This diagram illustrates how the combination of fibroblast growth factor 4 and ascorbic acid activates the JAK2–STAT3 signaling pathway, promoting the maturation of induced cardiomyocytes (iCMs). This approach effectively reprograms fibroblasts into cardiomyocytes with improved structure and function, offering exciting possibilities for regenerative medicine. Credit: The authors Cardiovascular disease...
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Age-related changes in fibroblast cells promote pancreatic cancer growth and spread
by Johns Hopkins University School of Medicine Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainOlder people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns...