September 6, 2024 by Johns Hopkins University School of Medicine Ashani Weeraratna, Ph.D. Credit: Will Kirk/JHU Age-related changes in the fibroblasts, cells that create the skin’s structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center. The study appears in Cell. The...
by Impact Journals LLC (A) Schematic representation of experimental design of senescence induction in the colon fibroblasts. Senescence was induced using hydrogen peroxide (H2O2, 400 μM), doxorubicin (doxo, 250 nM) or bleomycin (bleo, 10 ng/mL). Non-senescent proliferating (NS) cells were used as a control. (B) Representative SA- β -gal assay results at pH6 to confirm...
by Karolinska Institutet Credit: CC0 Public Domain Regular erections could be important for maintaining erectile function, according to a new study on mice published in Science by researchers at Karolinska Institutet. “We discovered that an increased frequency of erections leads to more fibroblasts that enable erection and vice versa, that a decreased frequency results in fewer...
by Perelman School of Medicine at the University of Pennsylvania Host ATF4 deletion inhibits tumor growth and extends survival.a, Top: loxP sites flank exons 2 and 3 of the Atf4 gene. Bottom: schematic of the tamoxifen treatment schedule. Tamoxifen (200 mg per kg body weight (BW) was given for 5 consecutive days by oral gavage. b, Box...
JOHNS HOPKINS MEDICINE ANCER CELLS GOBBLE UP LIPIDS. PROSTATE CELLS ARE STAINED WITH OIL-RED O TO DETECT LIPID DROPLETS. OUR WORK SHOWS THAT REDISTRIBUTION OF LIPIDS FROM PROSTATE CANCER MICROENVIRONMENT TRIGGERS INFLAMMATION AND… view more CREDIT: NICK (JIN-YIH) LOW Johns Hopkins Kimmel Cancer Centerresearchers from the Department of Radiation Oncology and Molecular Radiation Sciences identified...
UNIVERSITAT AUTONOMA DE BARCELONA An international study by the Institute of Neuroscience of the UAB (INC-UAB), Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from Lesch-Nyhan, a rare neurological disease, present biochemical alterations in skin cells (fibroblasts), urine and cerebrospinal fluid. Researchers have also discovered why these...
by University of Pennsylvania For most people who die of cancer, the spread of the initial tumor is to blame. “Metastasis is what kills most cancer patients,” says Serge Fuchs, a professor in Penn’s School of Veterinary Medicine. “Yet there are not many, if any, drugs that specifically target metastatic processes.” In a paper in...
by The Francis Crick Institute A key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread, has been identified by researchers at the Francis Crick Institute. The two studies, published in Nature Materials and PLOS Computational Biology, explain the mechanism that causes changes in the structure...
Preclinical research shows malignant cells’ tie to supportive fibroblasts can be hit with Calcitriol UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium...
