by NDORMS, University of Oxford Tissue sections show frozen shoulder patient tissues exhibit an increased number of cells and blood vessels relative to non-diseased comparator shoulder capsule. Credit: Prof. Stephanie DakinResearchers have identified how cells work to resolve frozen shoulder, opening up potential new targets for treatment and reducing the need for surgery. Frozen shoulder is...
Tag: <span>Fibrosis</span>
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Researchers examine how fibrosis affects heart’s natural pacemaker
by Amy Colgan, The Ohio State University Credit: Pixabay/CC0 Public Domain Researchers at The Ohio State University Wexner Medical Center have new insights into how the heart’s sinoatrial node (SAN), the body’s natural pacemaker, and its electrical signals are affected during heart failure. The SAN sends electrical signals through the heart, causing it to contract and pump...
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Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy (Boston)– Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation,...
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The CNIO pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) DEVELOPMENT OF THE INITIAL STAGES OF PULMONARY FIBROSIS ASSOCIATED WITH AGEING IN NON-TREATED MICE (LEFT), THAT CAN BE PREVENTED IN MICE TREATED WITH THE TELOMERASE GENE THERAPY (RIGHT). view more CREDIT: CNIO Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that...
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Chinese Study Finds COVID-19 Patients Still Suffer From Lung Damage Three Months After Being Discharged
A new study found the majority of Chinese patients recovering from COVID-19 still suffer from lung damage three months after being discharged from the hospital. Zhongnan Hospital of Wuhan University Intensive Care Director Dr. Peng Zhiyong published his findings on his research on the impact of COVID-19 on patients’ health after recovery. This was the...
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Researchers uncover how cells interact with supporting proteins to heal wounds
When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the process begins, which may provide...
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Cystic fibrosis: Why so many respiratory complications?
by University of Geneva The protein Vav3 (in green) creates «bacterial docking stations» on the surface (in red) of respiratory cells (nuclei in blue) that facilitate airways’ infection in patients with cystic fibrosis. Credit: UNIGE, laboratoire Chanson Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders. Despite...
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Not as gross as it sounds: predicting how bacteria in mucus affect human health
Inhale, exhale. Humans breathe between 17,000 to 23,000 times a day, on average. But for more than 70,000 children and young adults around the world, taking a breath can be a struggle because of a rare disease, cystic fibrosis. A gene that normally triggers a certain protein to move chloride, found in salt, to cell...
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New clues to lung-scarring disease may aid treatment
by Vanderbilt University Medical Center Scientists at Vanderbilt University Medical Center (VUMC) and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). Their findings, reported Wednesday, July 8, in the journal Science Advances, should aid the...
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Researchers find promising therapy to fight epidemic of liver disease
So far there are no approved drugs for Non-Alcoholic Fatty Liver Disease UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS AURORA, Colo. (July 8, 2020) – In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in...