by University of Virginia Hydrogel fabrication and subcutaneous implantation. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adf2675 A study from the University of Virginia’s Department of Biomedical Engineering has identified a critical mechanism driving fibrosis, or scarring, in response to medical implants made with biomaterial hydrogels. Their discovery, published in the June 14 issue of Science Advances, offers new hope for improving the...
Tag: <span>Fibrosis</span>
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Fibrosis lacks treatments and methods of reversal: Study pinpoints a promising target for drug therapy
September 23, 2024 by Delthia Ricks , Medical Xpress Model of MERTK mechanisms for regulating TGFβ core fibrotic pathway across various organs. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj0133Medical science has long been on the hunt for a deeper understanding of the devastating scarring of the body’s organs known as fibrosis, which leads to irrevocable...
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Study confirms fibrosis as a prognostic indicator in the most common breast cancer
September 19, 2024 by The Spanish National Cancer Research Centre Histological slide of cancerous breast tissue. The pink “riverways” are normal connective tissue, and the blue is cancer cells. Credit: Cecil Fox, National Cancer Institute (NIH).The most common breast cancer is HER2-negative, so called because it has low amounts of one of the proteins that...
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Frozen shoulder research may hold the key to understanding fibrosis resolution
by NDORMS, University of Oxford Tissue sections show frozen shoulder patient tissues exhibit an increased number of cells and blood vessels relative to non-diseased comparator shoulder capsule. Credit: Prof. Stephanie DakinResearchers have identified how cells work to resolve frozen shoulder, opening up potential new targets for treatment and reducing the need for surgery. Frozen shoulder is...
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Researchers examine how fibrosis affects heart’s natural pacemaker
by Amy Colgan, The Ohio State University Credit: Pixabay/CC0 Public Domain Researchers at The Ohio State University Wexner Medical Center have new insights into how the heart’s sinoatrial node (SAN), the body’s natural pacemaker, and its electrical signals are affected during heart failure. The SAN sends electrical signals through the heart, causing it to contract and pump...
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Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy (Boston)– Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation,...
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The CNIO pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) DEVELOPMENT OF THE INITIAL STAGES OF PULMONARY FIBROSIS ASSOCIATED WITH AGEING IN NON-TREATED MICE (LEFT), THAT CAN BE PREVENTED IN MICE TREATED WITH THE TELOMERASE GENE THERAPY (RIGHT). view more CREDIT: CNIO Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that...
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Chinese Study Finds COVID-19 Patients Still Suffer From Lung Damage Three Months After Being Discharged
A new study found the majority of Chinese patients recovering from COVID-19 still suffer from lung damage three months after being discharged from the hospital. Zhongnan Hospital of Wuhan University Intensive Care Director Dr. Peng Zhiyong published his findings on his research on the impact of COVID-19 on patients’ health after recovery. This was the...
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Researchers uncover how cells interact with supporting proteins to heal wounds
When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the process begins, which may provide...
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Cystic fibrosis: Why so many respiratory complications?
by University of Geneva The protein Vav3 (in green) creates «bacterial docking stations» on the surface (in red) of respiratory cells (nuclei in blue) that facilitate airways’ infection in patients with cystic fibrosis. Credit: UNIGE, laboratoire Chanson Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders. Despite...